ArticleProceedings of the National Academy of Sciences of the United States of America2015
Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- Synthesis of two methylolanthanin derivatives and the investigation of their lanthanide and iron binding capabilities.Dalton transactions (Cambridge, England : 2003) · 2026Article
- Biogeochemistry of Actinides: Recent Progress and Perspective.ACS environmental Au · 2024Review
- Actinium chelation and crystallization in a macromolecular scaffold.Nature communications · 2024Article
- Siderocalin fusion proteins enable a newRSC chemical biology · 2023Article
- Siderophore conjugates to combat antibiotic-resistant bacteria.RSC medicinal chemistry · 2023Review
- Use of an Acellular Assay to Study Interactions between Actinides and Biological or Synthetic Ligands.Biomolecules · 2022Article
- Engineering lanmodulin's selectivity for actinides over lanthanides by controlling solvent coordination and second-sphere interactions.Chemical science · 2022Article
- In situ beam reduction of Pu(IV) and Bk(IV) as a route to trivalent transuranic coordination complexes with hydroxypyridinone chelators.Journal of synchrotron radiation · 2022Article
- Capturing an elusive but critical element: Natural protein enables actinium chemistry.Science advances · 2021Article
- Efficient discrimination of transplutonium actinides byChemical science · 2021Article
- Open questions in transplutonium coordination chemistry.Communications chemistry · 2020Article
- Molecular dynamics simulations of plutonium binding and its decorporation from the binding-cleft of human serum transferrin.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020Article
- Fetuin exhibits a strong affinity for plutonium and may facilitate its accumulation in the skeleton.Scientific reports · 2019Article
- The Chemistry of Lanthanides in Biology: Recent Discoveries, Emerging Principles, and Technological Applications.ACS central science · 2019Review
- Interactions between 14 Elements in the Human Placenta, Fetal Membrane and Umbilical Cord.International journal of environmental research and public health · 2019Article
- The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity.Journal of innate immunity · 2019Review
- Chelation and stabilization of berkelium in oxidation state +IV.Nature chemistry · 2017Article
- Influence of Speciation of Thorium on Toxic Effects to Green Algae Chlorella pyrenoidosa.International journal of molecular sciences · 2017Article
- Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis.Cellular and molecular gastroenterology and hepatology · 2016Article
- Placental Metal Concentrations in Relation to Maternal and Infant Toenails in a U.S. Cohort.Environmental science & technology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, present severe health threats as contaminants, and understanding the scope of the biochemical interactions involved in actinide transport is instrumental in managing human contamination. Here we show that siderocalin, a mammalian siderophore-binding protein from the lipocalin family, specifically binds lanthanide and actinide complexes through molecular recognition of the ligands chelating the metal ions. Using crystallography, we structurally characterized the resulting siderocalin-transuranic actinide complexes, providing unprecedented insights into the biological coordination of heavy radioelements. In controlled in vitro assays, we found that intracellular plutonium uptake can occur through siderocalin-mediated endocytosis. We also demonstrated that siderocalin can act as a synergistic antenna to sensitize the luminescence of trivalent lanthanide and actinide ions in ternary protein-ligand complexes, dramatically increasing the brightness and efficiency of intramolecular energy transfer processes that give rise to metal luminescence. Our results identify siderocalin as a potential player in the biological trafficking of f elements, but through a secondary ligand-based metal sequestration mechanism. Beyond elucidating contamination pathways, this work is a starting point for the design of two-stage biomimetic platforms for photoluminescence, separation, and transport applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.