ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015
Limited Resection Versus Lobectomy for Older Patients With Early-Stage Lung Cancer: Impact of Histology.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60 citing papers in PubMed, 132 citations in OpenAlex.
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- CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma.Oncogenesis · 2025Article
- Long-term outcomes and patterns of failure after empiric SBRT for presumed early-stage lung tumors.Frontiers in oncology · 2025Article
- Choice of wedge resection for selected T1a/bN0M0 non-small cell lung cancer.Scientific reports · 2024Article
- A gene-based score for the risk stratification of stage IA lung adenocarcinoma.Respiratory research · 2024Article
- PB-LNet: a model for predicting pathological subtypes of pulmonary nodules on CT images.BMC cancer · 2023Article
- Surgeon Quality and Patient Survival After Resection for Non-Small-Cell Lung Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Article
- Development of the semi-dry dot-blot method for intraoperative detecting micropapillary component in lung adenocarcinoma based on proteomics analysis.British journal of cancer · 2023Article
- Efficacy of thoracoscopic segmentectomy versus lobectomy in the treatment of early invasive lung adenocarcinoma: a propensity score matching study.Frontiers in oncology · 2023Article
- Assessment of treatment strategies for stage I non-small cell lung cancer in patients with comorbidities.Lung cancer (Amsterdam, Netherlands) · 2022Article
- Optimizing the use of adjuvant chemotherapy in non-small cell lung cancer patients with comorbidities.Current problems in cancer · 2022Article
- Reappraising the clinical usability of consolidation-to-tumor ratio on CT in clinical stage IA lung cancer.Insights into imaging · 2022Article
- A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation-part 3: systematic review of evidence regarding surgery in compromised patients or specific tumors.Journal of thoracic disease · 2022Review
- Lobectomy versus segmentectomy in patients with stage T (> 2 cm and ≤ 3 cm) N0M0 non-small cell lung cancer: a propensity score matching study.Journal of cardiothoracic surgery · 2022Article
- The presenting dental status of solid tumours with bone metastases requiring bone-targeting agents - part 4: miscellaneous cancers.British dental journal · 2022Article
- Trend of lung cancer surgery, hospital selection, and survival between 2005 and 2016 in South Korea.Thoracic cancer · 2022Article
- Subsegmentectomy versus segmentectomy resection for the treatment of operable patients with stage IA non-small cell lung cancer: A meta-analysis.Frontiers in surgery · 2022Review
- Construction of a mortality risk prediction model for elderly people at risk of lobectomy for NSCLC.Frontiers in surgery · 2022Article
- Selection of the surgical approach for patients with cStage IA lung squamous cell carcinoma: A population-based propensity score matching analysis.Frontiers in oncology · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeLimited resection has been increasingly used in older patients with stage IA lung cancer. However, the equivalency of limited resection versus lobectomy according to histology is unknown.
methodsWe identified patients older than 65 years with stage IA invasive adenocarcinoma or squamous cell carcinoma ≤ 2 cm who were treated with limited resection (wedge or segmentectomy) or lobectomy in the Surveillance, Epidemiology, and End Results-Medicare database. We estimated propensity scores that predicted the use of limited resection and compared survival of patients treated with limited resection versus lobectomy. Treatments were considered equivalent if the upper 95th percentile of the hazard ratio (HR) for limited resection was ≤ 1.25.
resultsOverall, 27% of 2,008 patients with adenocarcinoma and 32% of 1,139 patients with squamous cell carcinoma underwent limited resection. Survival analyses, adjusted for propensity score by using inverse probability weighting, showed that limited resection was not equivalent to lobectomy in patients with adenocarcinoma (HR, 1.21; upper 95% CI,1.34) or squamous cell carcinoma (HR, 1.21; upper 95% CI, 1.39). Although patients with adenocarcinomas treated with segmentectomy had equivalent survival rates to those treated with lobectomy (HR, 0.97; upper 95% CI, 1.07), outcomes of those treated with wedge resection (HR, 1.29; upper 95% CI, 1.42) did not. Among patients with squamous cell carcinoma, neither wedge resection (HR, 1.34; upper 95% CI, 1.53) nor segmentectomy (HR, 1.19; upper 95% CI, 1.36) were equivalent to lobectomy.
conclusionWe found generally that limited resection is not equivalent to lobectomy in older patients with invasive non-small-cell lung cancer ≤ 2 cm in size, although segmentectomy may be equivalent in patients with adenocarcinoma.
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