Evidence map›Paper›PMID 26240155›Full record

ArticleThe American journal of tropical medicine and hygiene2015

An Economic Evaluation of the Posttreatment Prophylactic Effect of Dihydroartemisinin-Piperaquine Versus Artemether-Lumefantrine for First-Line Treatment of Plasmodium falciparum Malaria Across Different Transmission Settings in Africa.

Johannes Pfeil, Steffen Borrmann, Quique Bassat, Modest Mulenga, Ambrose Talisuna, Yesim Tozan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Efficacy of Artemether-Lumefantrine on variousParasite epidemiology and control · 2020
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Johannes PfeilParasitology Unit, Department for Infectious Diseases, University Hospital Heidelberg, Heidelberg, Germany; General Pediatrics Unit, Center for Childhood and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany; German Centre for Infectious Diseases (DZIF), University of Tübingen, Tübingen, Germany; ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique; Tropical Diseases Research Centre, Ndola, Zambia; Department of Public Health Research, University of Oxford-KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya; Steinhardt School of Culture, Education and Human Development, New York University, New York, New York; College of Global Public Health, New York University, New York, New York; Institute of Public Health, Ruprecht-Karls-University, Heidelberg, Germany.
Steffen BorrmannParasitology Unit, Department for Infectious Diseases, University Hospital Heidelberg, Heidelberg, Germany; General Pediatrics Unit, Center for Childhood and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany; German Centre for Infectious Diseases (DZIF), University of Tübingen, Tübingen, Germany; ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique; Tropical Diseases Research Centre, Ndola, Zambia; Department of Public Health Research, University of Oxford-KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya; Steinhardt School of Culture, Education and Human Development, New York University, New York, New York; College of Global Public Health, New York University, New York, New York; Institute of Public Health, Ruprecht-Karls-University, Heidelberg, Germany.
Quique BassatParasitology Unit, Department for Infectious Diseases, University Hospital Heidelberg, Heidelberg, Germany; General Pediatrics Unit, Center for Childhood and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany; German Centre for Infectious Diseases (DZIF), University of Tübingen, Tübingen, Germany; ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique; Tropical Diseases Research Centre, Ndola, Zambia; Department of Public Health Research, University of Oxford-KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya; Steinhardt School of Culture, Education and Human Development, New York University, New York, New York; College of Global Public Health, New York University, New York, New York; Institute of Public Health, Ruprecht-Karls-University, Heidelberg, Germany.
Modest MulengaParasitology Unit, Department for Infectious Diseases, University Hospital Heidelberg, Heidelberg, Germany; General Pediatrics Unit, Center for Childhood and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany; German Centre for Infectious Diseases (DZIF), University of Tübingen, Tübingen, Germany; ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique; Tropical Diseases Research Centre, Ndola, Zambia; Department of Public Health Research, University of Oxford-KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya; Steinhardt School of Culture, Education and Human Development, New York University, New York, New York; College of Global Public Health, New York University, New York, New York; Institute of Public Health, Ruprecht-Karls-University, Heidelberg, Germany.
Ambrose TalisunaParasitology Unit, Department for Infectious Diseases, University Hospital Heidelberg, Heidelberg, Germany; General Pediatrics Unit, Center for Childhood and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany; German Centre for Infectious Diseases (DZIF), University of Tübingen, Tübingen, Germany; ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique; Tropical Diseases Research Centre, Ndola, Zambia; Department of Public Health Research, University of Oxford-KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya; Steinhardt School of Culture, Education and Human Development, New York University, New York, New York; College of Global Public Health, New York University, New York, New York; Institute of Public Health, Ruprecht-Karls-University, Heidelberg, Germany.
Yesim TozanParasitology Unit, Department for Infectious Diseases, University Hospital Heidelberg, Heidelberg, Germany; General Pediatrics Unit, Center for Childhood and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany; German Centre for Infectious Diseases (DZIF), University of Tübingen, Tübingen, Germany; ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique; Tropical Diseases Research Centre, Ndola, Zambia; Department of Public Health Research, University of Oxford-KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya; Steinhardt School of Culture, Education and Human Development, New York University, New York, New York; College of Global Public Health, New York University, New York, New York; Institute of Public Health, Ruprecht-Karls-University, Heidelberg, Germany tozan@nyu.edu.
Heidelberg University · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria disproportionately affects young children. Clinical trials in African children showed that dihydroartemisinin-piperaquine (DP) is an effective antimalarial and has a longer posttreatment prophylactic (PTP) effect against reinfections than other artemisinin-based combination therapies, including artemether-lumefantrine (AL). Using a previously developed Markov model and individual patient data from a multicenter African drug efficacy trial, we assessed the economic value of the PTP effect of DP versus AL in pediatric malaria patients from health-care provider's perspective in low-to-moderate and moderate-to-high transmission settings under different drug co-payment scenarios. In low-to-moderate transmission settings, first-line treatment with DP was highly cost-effective with an incremental cost-effectiveness ratio of US$5 (95% confidence interval [CI] = -76 to 196) per disability-adjusted life year (DALY) averted. In moderate-to-high transmission settings, DP first-line treatment led to a mean cost saving of US$1.09 (95% CI = -0.88 to 3.85) and averted 0.05 (95% CI = -0.08 to 0.22) DALYs per child per year. Our results suggested that DP might be superior to AL for first-line treatment of uncomplicated childhood malaria across a range of transmission settings in Africa.

Indexed as

AntimalarialsArtemether, Lumefantrine Drug CombinationArtemisininsChildDrug CombinationsEthanolaminesFluorenesHumansMalaria, FalciparumMarkov ChainsModels, BiologicalModels, EconomicPiperazinesPlasmodium falciparumQuinolinesRecurrenceAntimalarialsArtemether, Lumefantrine Drug CombinationArtemisininsartenimolDrug CombinationsEthanolaminesFluorenespiperaquinePiperazinesQuinolines

Identifiers

PMID26240155
PMCPMC4703290
OpenAlexW1822671023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.