ArticleBrain imaging and behavior2016
Cardiorespiratory fitness and white matter integrity in Alzheimer's disease.
Article in Brain imaging and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- [Effect of physical exercise on Alzheimer's disease. A sistematic review].Atencion primaria · 2020Pooled it
- Cerebral changes improved by physical activity during cognitive decline: A systematic review on MRI studies.NeuroImage. Clinical · 2019Pooled it
- Effect of physical exercise on white matter microstructure in chemotherapy-treated breast cancer patients: a randomized controlled trial (PAM study).Brain imaging and behavior · 2025Trial
- Associations of cardiorespiratory fitness with structural brain networks in ageing: insights from The Maastricht Study.GeroScience · 2026Article
- Alzheimer's Disease: Understanding Motor Impairments.Brain sciences · 2024Review
- Evidence of association between higher cardiorespiratory fitness and higher cerebral myelination in aging.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The effect of physical activity on white matter integrity in aging and prodromal to mild Alzheimer's disease with vascular comorbidity.Frontiers in aging neuroscience · 2023Article
- Aerobic exercise, cardiorespiratory fitness, and the human hippocampus.Hippocampus · 2021Review
- Physical Exercise and Alzheimer's Disease: Effects on Pathophysiological Molecular Pathways of the Disease.International journal of molecular sciences · 2021Review
- Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter.Frontiers in aging neuroscience · 2021Article
- Interaction between physical exercise and APOE gene polymorphism on cognitive function in older people.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Review
- Functional connectivity between white matter and gray matter based on fMRI for Alzheimer's disease classification.Brain and behavior · 2019Article
- An Overview of the Cardiorespiratory Hypothesis and Its Potential Contribution to the Care of Neurodegenerative Disease in Africa.Medicina (Kaunas, Lithuania) · 2019Review
- Non-Aβ-Dependent Factors Associated with Global Cognitive and Physical Function in Alzheimer's Disease: A Pilot Multivariate Analysis.Journal of clinical medicine · 2019Article
- Cardiorespiratory fitness attenuates age-associated aggregation of white matter hyperintensities in an at-risk cohort.Alzheimer's research & therapy · 2018Article
- Relation between aerobic fitness and brain structures in amnestic mild cognitive impairment elderly.Age (Dordrecht, Netherlands) · 2016Article
- White matter microstructure mediates the association between cardiorespiratory fitness and cognitive performance in older adults.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The objective of this study was to investigate the relationship between cardiorespiratory (CR) fitness and the brain's white matter tract integrity using diffusion tensor imaging (DTI) in the Alzheimer's disease (AD) population. We recruited older adults in the early stages of AD (n = 37; CDR = 0.5 and 1) and collected cross-sectional fitness and diffusion imaging data. We examined the association between CR fitness (peak oxygen consumption [VO2peak]) and fractional anisotropy (FA) in AD-related white matter tracts using two processing methodologies: a tract-of-interest approach and tract-based spatial statistic (TBSS). Subsequent diffusivity metrics (radial diffusivity [RD], mean diffusivity [MD], and axial diffusivity [A × D]) were also correlated with VO2peak. The tract-of-interest approach showed that higher VO2peak was associated with preserved white matter integrity as measured by increased FA in the right inferior fronto-occipital fasciculus (p = 0.035, r = 0.36). We did not find a significant correlation using TBSS, though there was a trend for a positive association between white matter integrity and higher VO2peak measures (p < 0.01 uncorrected). Our findings indicate that higher CR fitness levels in early AD participants may be related to preserved white matter integrity. However to draw stronger conclusions, further study on the relationship between fitness and white matter deterioration in AD is necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.