Evidence map›Paper›PMID 26239990›Full record

Observational studyAntimicrobial agents and chemotherapy2015

Population Pharmacokinetics of Fosfomycin in Critically Ill Patients.

Suzanne L Parker, Frantzeska Frantzeskaki, Steven C Wallis, Chryssa Diakaki, Helen Giamarellou, Despoina Koulenti, Ilias Karaiskos, Jeffrey Lipman, George Dimopoulos, Jason A Roberts

Open access · bronzeAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Suzanne L ParkerBurns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia.
Frantzeska FrantzeskakiCritical Care Department, Attikon University Hospital, Athens, Greece Medical School, University of Athens, Athens, Greece.
Steven C WallisBurns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia.
Chryssa DiakakiCritical Care Department, Attikon University Hospital, Athens, Greece Medical School, University of Athens, Athens, Greece.
Helen Giamarellou6th Department of Internal Medicine, Hygeia General Hospital, Athens, Greece.
Despoina KoulentiBurns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Critical Care Department, Attikon University Hospital, Athens, Greece.
Ilias Karaiskos6th Department of Internal Medicine, Hygeia General Hospital, Athens, Greece.
Jeffrey LipmanBurns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Royal Brisbane and Women's Hospital, Brisbane, Australia.
George DimopoulosCritical Care Department, Attikon University Hospital, Athens, Greece Medical School, University of Athens, Athens, Greece.
Jason A RobertsBurns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Royal Brisbane and Women's Hospital, Brisbane, Australia j.roberts2@uq.edu.au.
University of Queensland · AUUniversity General Hospital Attikon · GRHygeia Hospital · GRRoyal Brisbane and Women's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study describes the population pharmacokinetics of fosfomycin in critically ill patients. In this observational study, serial blood samples were taken over several dosing intervals of intravenous fosfomycin treatment. Blood samples were analyzed using a validated liquid chromatography-tandem mass spectrometry technique. A population pharmacokinetic analysis was performed using nonlinear mixed-effects modeling. Five hundred fifteen blood samples were collected over one to six dosing intervals from 12 patients. The mean (standard deviation) age was 62 (17) years, 67% of patients were male, and creatinine clearance (CLCR) ranged from 30 to 300 ml/min. A two-compartment model with between-subject variability on clearance and volume of distribution of the central compartment (Vc) described the data adequately. Calculated CLCR was supported as a covariate on fosfomycin clearance. The mean parameter estimates for clearance on the first day were 2.06 liters/h, Vc of 27.2 liters, intercompartmental clearance of 19.8 liters/h, and volume of the peripheral compartment of 22.3 liters. We found significant pharmacokinetic variability for fosfomycin in this heterogeneous patient sample, which may be explained somewhat by the observed variations in renal function.

Indexed as

Models, StatisticalAgedAnti-Bacterial AgentsAPACHEBiological AvailabilityCritical IllnessDrug Administration ScheduleFemaleFosfomycinGram-Negative Bacterial InfectionsGram-Positive Bacterial InfectionsGreeceHumansIntensive Care UnitsMaleMiddle AgedAnti-Bacterial AgentsFosfomycin

Identifiers

PMID26239990
PMCPMC4576076
OpenAlexW1903855728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.