Evidence map›Paper›PMID 26239846›Full record

ArticleDiagnostic microbiology and infectious disease2015

Incubation time of Mycobacterium tuberculosis complex sputum cultures in BACTEC MGIT 960: 4weeks of negative culture is enough for physicians to consider alternative diagnoses.

Sam Ogwang, Paul Mubiri, Charles M Bark, Moses L Joloba, W Henry Boom, John L Johnson

Abstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. The Challenges of Diagnosing Tuberculous Meningitis and Importance of Early Intervention.Journal of community hospital internal medicine perspectives · 2023
    Article
  7. Review
  8. Time to Detection of Growth forFrontiers in cellular and infection microbiology · 2021
    Article
  9. Article
  10. Article
  11. Factors Associated with Missed Detection ofBioMed research international · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sam OgwangUganda-Case Western Reserve University Research Collaboration, Makerere University, Kampala, Uganda; Joint Clinical Research Centre, Kampala, Uganda. Electronic address: sxo81@case.edu.
Paul MubiriUganda-Case Western Reserve University Research Collaboration, Makerere University, Kampala, Uganda; Joint Clinical Research Centre, Kampala, Uganda.
Charles M BarkUganda-Case Western Reserve University Research Collaboration, Makerere University, Kampala, Uganda; Division of Infectious Diseases, Metro Health Medical Center, Cleveland, OH, USA; Tuberculosis Research Unit, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH, USA.
Moses L JolobaUganda-Case Western Reserve University Research Collaboration, Makerere University, Kampala, Uganda; Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda.
W Henry BoomUganda-Case Western Reserve University Research Collaboration, Makerere University, Kampala, Uganda; Tuberculosis Research Unit, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH, USA.
John L JohnsonUganda-Case Western Reserve University Research Collaboration, Makerere University, Kampala, Uganda; Tuberculosis Research Unit, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH, USA.

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Clinical and Translational Science Collaborative of ClevelandKL2TR000440 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$11.1M
Tuberculosis Prevention Research Unit /TBRU/-266095383N01AI095383 · NIAID · CASE WESTERN RESERVE UNIVERSITY · 2000 to 2005
$5.6M
NCATS NIH HHS KL2 TR000440NCATS NIH HHS UL1 TR000439NIAID NIH HHS N01 AI070022NIAID NIH HHS N01 AI095383
6 · The paper itself

Abstract

We retrospectively analyzed time to detection of 3747 positive MGIT sputum cultures at a laboratory in a country with heavy burden of tuberculosis. Ninety-nine percent of diagnostic cultures turned positive within 28days, suggesting that physicians may consider alternative diagnoses if sputum cultures remain negative after 4weeks of incubation.

Indexed as

Bacteriological TechniquesHumansMycobacterium tuberculosisRetrospective StudiesSputumTime FactorsTuberculosisMGIT 960MTB complexSputum cultureTTD

Identifiers

PMID26239846
PMCPMC4573350

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.