ArticleJournal of clinical medicine2015
Hypopituitarism in Traumatic Brain Injury-A Critical Note.
Article in Journal of clinical medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Shock index and its variants as predictors of mortality in severe traumatic brain injury.World journal of critical care medicine · 2024Article
- Organoid models of the pituitary gland in health and disease.Frontiers in endocrinology · 2023Review
- Experience of a Pituitary Clinic for US Military Veterans With Traumatic Brain Injury.Journal of the Endocrine Society · 2021Article
- Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study.International journal of methods in psychiatric research · 2019Observational
- Low Prevalence of Isolated Growth Hormone Deficiency in Patients After Brain Injury: Results From a Phase II Pilot Study.Frontiers in endocrinology · 2018Article
- The prevalence of growth hormone deficiency in survivors of subarachnoid haemorrhage: results from a large single centre study.Pituitary · 2017Article
- Pituitary insufficiency following traumatic thoracic injury in an adolescent male patient: A case report and literature review.Medicine · 2017Review
- Pituitary function within the first year after traumatic brain injury or subarachnoid haemorrhage.Journal of endocrinological investigation · 2017Article
- Advances in understanding hypopituitarism.F1000Research · 2017Review
- Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population.International journal of endocrinology · 2017Article
- Central hypothyroidism and its role for cardiovascular risk factors in hypopituitary patients.Endocrine · 2016Review
- Social dysfunction after pediatric traumatic brain injury: A translational perspective.Neuroscience and biobehavioral reviews · 2016Review
- Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report.International journal of molecular sciences · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While hypopituitarism after traumatic brain injury (TBI) was previously considered rare, it is now thought to be a major cause of treatable morbidity among TBI survivors. Consequently, recommendations for assessment of pituitary function and replacement in TBI were recently introduced. Given the high incidence of TBI with more than 100 pr. 100,000 inhabitants, TBI would be by far the most common cause of hypopituitarism if the recently reported prevalence rates hold true. The disproportion between this proposed incidence and the occasional cases of post-TBI hypopituitarism in clinical practice justifies reflection as to whether hypopituitarism has been unrecognized in TBI patients or whether diagnostic testing designed for high risk populations such as patients with obvious pituitary pathology has overestimated the true risk and thereby the disease burden of hypopituitarism in TBI. The findings on mainly isolated deficiencies in TBI patients, and particularly isolated growth hormone (GH) deficiency, raise the question of the potential impact of methodological confounding, determined by variable test-retest reproducibility, appropriateness of cut-off values, importance of BMI stratified cut-offs, assay heterogeneity, pre-test probability of hypopituitarism and lack of proper individual laboratory controls as reference population. In this review, current recommendations are discussed in light of recent available evidence.
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