Evidence map›Paper›PMID 26239580›Full record

ArticleThe American journal of cardiology2015

Comparison of Outcomes in Patients With Nonobstructive, Labile-Obstructive, and Chronically Obstructive Hypertrophic Cardiomyopathy.

Iraklis Pozios, Celia Corona-Villalobos, Lars L Sorensen, Paco E Bravo, Marco Canepa, Chiara Pisanello, Aurelio Pinheiro, Veronica L Dimaano, Hongchang Luo, Zeina Dardari and 6 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Iraklis PoziosJohns Hopkins HCM Center of Excellence, Baltimore, Maryland.
Celia Corona-VillalobosDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
Lars L SorensenJohns Hopkins HCM Center of Excellence, Baltimore, Maryland.
Paco E BravoDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
Marco CanepaJohns Hopkins HCM Center of Excellence, Baltimore, Maryland.
Chiara PisanelloJohns Hopkins HCM Center of Excellence, Baltimore, Maryland.
Aurelio PinheiroJohns Hopkins HCM Center of Excellence, Baltimore, Maryland.
Veronica L DimaanoJohns Hopkins HCM Center of Excellence, Baltimore, Maryland.
Hongchang LuoJohns Hopkins HCM Center of Excellence, Baltimore, Maryland.
Zeina DardariJohns Hopkins HCM Center of Excellence, Baltimore, Maryland.
Xun ZhouJohns Hopkins HCM Center of Excellence, Baltimore, Maryland.
Ihab KamelDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
Stefan L ZimmermanDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland.
David A BluemkeRadiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Maryland.
M Roselle AbrahamJohns Hopkins HCM Center of Excellence, Baltimore, Maryland.
Theodore P AbrahamJohns Hopkins HCM Center of Excellence, Baltimore, Maryland. Electronic address: tabraha3@jhmi.edu.
Johns Hopkins University · USNational Institutes of Health Clinical Center · US

Funding

Molecular Biomedical Imaging Laboratory (NIBIB)ZIAEB000072 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI BLUEMKE, DAVID · 2010 to 2017
$5.0M
Development of a Hypertrophic Cardiomyopathy ConsortiumR01HL098046 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ABRAHAM, THEODORE P · 2010 to 2012
$953k
Molecular Biomedical Imaging Laboratory (CC)ZIACL090019 · CLC · CLINICAL CENTER · PI JONES, ELIZABETH C. · 2010 to 2017
$0k
NHLBI NIH HHS HL 098046NHLBI NIH HHS R01 HL098046
6 · The paper itself

Abstract

Patients with nonobstructive hypertrophic cardiomyopathy (HC) are considered low risk, generally not requiring aggressive intervention. However, nonobstructive and labile-obstructive HC have been traditionally classified together, and it is unknown if these 2 subgroups have distinct risk profiles. We compared cardiovascular outcomes in 293 patients HC (96 nonobstructive, 114 labile-obstructive, and 83 obstructive) referred for exercise echocardiography and magnetic resonance imaging and followed for 3.3 ± 3.6 years. A subgroup (34 nonobstructive, 28 labile-obstructive, 21 obstructive) underwent positron emission tomography. The mean number of sudden cardiac death risk factors was similar among groups (nonobstructive: 1.4 vs labile-obstructive: 1.2 vs obstructive: 1.4 risk factors, p = 0.2). Prevalence of late gadolinium enhancement (LGE) was similar across groups but more non-obstructive patients had late gadolinium enhancement ≥20% of myocardial mass (23 [30%] vs 19 [18%] labile-obstructive and 8 [11%] obstructive, p = 0.01]. Fewer labile-obstructive patients had regional positron emission tomography perfusion abnormalities (12 [46%] vs nonobstructive 30 [81%] and obstructive 17 [85%], p = 0.003]. During follow-up, 60 events were recorded (36 ventricular tachycardia/ventricular fibrillation, including 30 defibrillator discharges, 12 heart failure worsening, and 2 deaths). Nonobstructive patients were at greater risk of VT/VF at follow-up, compared to labile obstructive (hazed ratio 0.18, 95% confidence interval 0.04 to 0.84, p = 0.03) and the risk persisted after adjusting for age, gender, syncope, family history of sudden cardiac death, abnormal blood pressure response, and septum ≥3 cm (p = 0.04). Appropriate defibrillator discharges were more frequent in nonobstructive (8 [18%]) compared to labile-obstructive (0 [0%], p = 0.02) patients. In conclusion, nonobstructive hemodynamics is associated with more pronounced fibrosis and ischemia than labile-obstructive and is an independent predictor of VT/VF in HC.

Indexed as

AdultAgedCardiomyopathy, HypertrophicCohort StudiesDisease ProgressionEchocardiography, StressFemaleHeartHeart FailureHumansKaplan-Meier EstimateMagnetic Resonance ImagingMaleMiddle AgedMyocardial Perfusion ImagingMyocardium

Identifiers

PMID26239580
PMCPMC4554842
OpenAlexW1869337218

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.