ReviewJournal of clinical medicine2015
Vitamin D and the Development of Atopic Eczema.
Review in Journal of clinical medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- The Hidden Pathway: Membrane Vitamin D Receptor Deficiency and T-Cell Senescence in Pediatric Atopic Dermatitis - A Retrospective and Cross-Sectional Investigation.Journal of asthma and allergy · 2026Article
- Vitamin D and the aging skin: insights into oxidative stress, inflammation, and barrier function.Immunity & ageing : I & A · 2025Review
- VITAMIN D IN PATIENTS WITH INFLAMMATORY SKIN DISEASES.Acta clinica Croatica · 2025Review
- Advanced Systemic Treatments in Patients with Moderate-to-Severe Atopic Dermatitis: Key Learnings from Physicians Practicing in Nine Asian Countries and Territories.Dermatology and therapy · 2024Article
- Vitamin D Receptor Regulates the Expression of the Grainyhead-Like 1 Gene.International journal of molecular sciences · 2024Article
- Association between Vitamin D Receptor Polymorphisms, Tight Junction Proteins and Clinical Features of Adult Patients with Atopic Dermatitis.Dermatology practical & conceptual · 2024Article
- Effective counseling for children's bone health.Journal of the Pediatric Orthopaedic Society of North America · 2024Article
- Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.Nutrients · 2024Article
- Associations of single and multiple vitamin exposure with childhood eczema: data from the national health and nutrition examination survey.Frontiers in pediatrics · 2024Article
- Sex and obesity status modify the association between vitamin D and eczema among adolescents.Pediatric research · 2023Article
- Review
- The burden of asthma, hay fever and eczema in children in 25 countries: GAN Phase I study.The European respiratory journal · 2022Article
- Maternal Nutritional Status and Development of Atopic Dermatitis in Their Offspring.Clinical reviews in allergy & immunology · 2021Review
- Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children's Study.Nutrients · 2021Article
- Causal Analysis Shows Evidence of Atopic Dermatitis Leading to an Increase in Vitamin D Levels.The Journal of investigative dermatology · 2021Article
- Prevention of Atopic Dermatitis.Acta dermato-venereologica · 2020Review
- Interleukin 1-β, interleukin-1 receptor antagonist and vitamin D levels in children with atopic dermatitis.Central-European journal of immunology · 2018Article
- The role of geographical ecological studies in identifying diseases linked to UVB exposure and/or vitamin D.Dermato-endocrinologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A "vitamin D hypothesis" has been proposed to explain the increased prevalence of eczema in regions with higher latitude. This review focuses on the current available evidence with regard to the possible effect of vitamin D on the development of atopic eczema. Observational studies have indicated a link between vitamin D status and eczema outcomes, including lower serum vitamin D levels associated with increased incidence and severity of eczema symptoms. Vitamin D is known to have a regulatory influence on both the immune system and skin barrier function, both critical in the pathogenesis of eczema. However heterogeneous results have been found in studies to date investigating the effect of vitamin D status during pregnancy and infancy on the prevention of eczema outcomes. Well-designed, adequately powered, randomised controlled trials are needed. The study design of any new intervention trials should measure vitamin D levels at multiple time points during the intervention, ultraviolet (UV) radiation exposure via the use of individual UV dosimeters, and investigate the role of individual genetic polymorphisms. In conclusion, the current available evidence does not allow firm conclusions to be made on whether vitamin D status affects the development of atopic eczema.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.