Evidence map›Paper›PMID 26239293›Full record

ArticleMolecular psychiatry2016

A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence.

S L Spain, I Pedroso, N Kadeva, M B Miller, W G Iacono, M McGue, E Stergiakouli, G Davey Smith, M Putallaz, D Lubinski and 3 more

Erratum issuedAbstract read
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In one paragraph

Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Genes, culture, and scientific racism.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. The new genetics of intelligence.Nature reviews. Genetics · 2018
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

S L SpainDepartment of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King's College London, London, UK.
I PedrosoDepartment of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King's College London, London, UK.
N KadevaDepartment of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King's College London, London, UK.
M B MillerDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
W G IaconoDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
M McGueDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
E StergiakouliMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
G Davey SmithMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
M PutallazDuke University Talent Identification Program, Duke University, Durham, NC, USA.
D LubinskiDepartment of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
E L MeaburnDepartment of Psychological Sciences, Birkbeck, University of London, London, UK.
R PlominMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
M A SimpsonDepartment of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King's College London, London, UK.

Funding

Substance Abuse & Behavioral Disinhibition: Integrating Genes & EnvironmentU01DA024417 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2007 to 2010
$10.8M
TWIN STUDY OF FEMALE ALCOHOLISMS AND OTHER DISORDERSR01AA009367 · NIAAA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 1992 to 2013
$9.0M
Twin Family Study of Vulnerability to Substance AbuseR37DA005147 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2009 to 2018
$6.4M
A Longitudinal Study of Adopted Youth and Their FamiliesR01MH066140 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 2003 to 2013
$5.8M
TWIN/FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSER01DA005147 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI IACONO, WILLIAM G · 1987 to 2007
$5.5M
Adolescent drinking and midlife outcomes: A prospective cotwin control studyR37AA009367 · NIAAA · UNIVERSITY OF MINNESOTA · PI MCGUE, MATTHEW K. · 2016 to 2024
$5.4M
TWIN STUDY OF ADHD, CD, AND SUBSTANCE ABUSER01DA013240 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI IACONO, WILLIAM G. · 2000 to 2010
$5.0M
Adult consequences of youth substance use: Twin study enriched for SUD riskR01DA036216 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2013 to 2017
$3.2M
SIBLING MODELS OF ADOLESCENT ALCOHOL USE AND ABUSER01AA011886 · NIAAA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 1998 to 2008
$2.5M
Substance Abuse & Behavioral Disinhibition: Integrating Genes & EnvironmentR01DA024417 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2011 to 2011
$1.6M
European Research Council 295366Medical Research Council 092731Medical Research Council G0500079Medical Research Council G0901245Medical Research Council G19/2Medical Research Council MC_PC_15018Medical Research Council MC_UU_12013/1NIAAA NIH HHS R01 AA009367NIAAA NIH HHS R01 AA011886NIAAA NIH HHS R37 AA009367NIDA NIH HHS R01 DA005147NIDA NIH HHS R01 DA013240NIDA NIH HHS R01 DA024417NIDA NIH HHS R01 DA036216NIDA NIH HHS R37 DA005147NIDA NIH HHS U01 DA024417NIMH NIH HHS R01 MH066140Wellcome Trust 102215
6 · The paper itself

Abstract

Although individual differences in intelligence (general cognitive ability) are highly heritable, molecular genetic analyses to date have had limited success in identifying specific loci responsible for its heritability. This study is the first to investigate exome variation in individuals of extremely high intelligence. Under the quantitative genetic model, sampling from the high extreme of the distribution should provide increased power to detect associations. We therefore performed a case-control association analysis with 1409 individuals drawn from the top 0.0003 (IQ >170) of the population distribution of intelligence and 3253 unselected population-based controls. Our analysis focused on putative functional exonic variants assayed on the Illumina HumanExome BeadChip. We did not observe any individual protein-altering variants that are reproducibly associated with extremely high intelligence and within the entire distribution of intelligence. Moreover, no significant associations were found for multiple rare alleles within individual genes. However, analyses using genome-wide similarity between unrelated individuals (genome-wide complex trait analysis) indicate that the genotyped functional protein-altering variation yields a heritability estimate of 17.4% (s.e. 1.7%) based on a liability model. In addition, investigation of nominally significant associations revealed fewer rare alleles associated with extremely high intelligence than would be expected under the null hypothesis. This observation is consistent with the hypothesis that rare functional alleles are more frequently detrimental than beneficial to intelligence.

Indexed as

AdultAllelesCognitionExomeExonsFemaleGene FrequencyGenetic VariationGenome-Wide Association StudyGenotypeHumansIntelligenceMaleMultifactorial InheritancePolymorphism, Single NucleotideQuantitative Trait, Heritable

Identifiers

PMID26239293
PMCPMC4650257

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.