Evidence map›Paper›PMID 26239179›Full record

ArticleNeurobiology of aging2015

Inherited mtDNA variations are not strong risk factors in human prion disease.

Gavin Hudson, James Uphill, Holger Hummerich, Janice Blevins, Pierluigi Gambetti, Inga Zerr, John Collinge, Simon Mead, Patrick F Chinnery

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In one paragraph

Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Gavin HudsonWellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, UK.
James UphillMRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Holger HummerichMRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Janice BlevinsDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Pierluigi GambettiDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Inga ZerrClinical Dementia Center, Department of Neurology, Georg-August University Göttingen, Göttingen, Germany; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich Munich, Germany.
John CollingeMRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Simon MeadMRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. Electronic address: s.mead@prion.ucl.ac.uk.
Patrick F ChinneryWellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, UK.
MRC Prion Unit · GBCase Western Reserve University · USLudwig-Maximilians-Universität München · DENewcastle University · GBUniversity College London · GBWellcome Centre for Mitochondrial Research · GB

Funding

Medical Research Council G0601943Medical Research Council MC_U123160651Medical Research Council MC_U123160657Medical Research Council MC_UP_1501/2Parkinson's UK F-1202Wellcome Trust 096919Z/11/ZWellcome Trust 101876
6 · The paper itself

Abstract

Aside from variation in the prion protein gene, genetic risk factors for sporadic Creutzfeldt-Jakob disease remain elusive. Given emerging evidence implicating mitochondrial dysfunction in the pathogenesis of the disorders, we studied the role of inherited mitochondrial DNA variation in a 2255 sporadic prion disease cases and 3768 controls. Our analysis indicates that inherited mitochondrial DNA variation does not have a major role in the risk of developing the disorder.

Indexed as

Genetic Association StudiesCohort StudiesDNA, MitochondrialGenetic VariationHumansPrion DiseasesRisk FactorsDNA, MitochondrialCJDGWASMitochondrialPrion

Identifiers

PMID26239179
PMCPMC6542657
OpenAlexW2101748012

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.