ArticleMedical & biological engineering & computing2016
Specimen-specific vertebral fracture modeling: a feasibility study using the extended finite element method.
Article in Medical & biological engineering & computing, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Finite element modeling and experimental validation of wedge fractures in the thoracic spine.Spine deformity · 2026Article
- Gender differences in L1 vertebral strength in adults 50+ using automated CT-based finite element analysis.Scientific reports · 2025Article
- Experimentally Validated Finite Element Analysis of Thoracic Spine Compression Fractures in a Porcine Model.Bioengineering (Basel, Switzerland) · 2024Article
- How to Optimize Pedicle Screw Parameters for the Thoracic Spine? A Biomechanical and Finite Element Method Study.Global spine journal · 2024Article
- A Review of CT-Based Fracture Risk Assessment with Finite Element Modeling and Machine Learning.Current osteoporosis reports · 2022Review
- Incremental Element Deletion-Based Finite Element Analysis of the Effects of Impact Speeds, Fall Postures, and Cortical Thicknesses on Femur Fracture.Materials (Basel, Switzerland) · 2022Article
- Establishment and validation of a T12-L2 3D finite element model for thoracolumbar segments.American journal of translational research · 2022Article
- Opportunistic application of phantom-less calibration methods for fracture risk prediction using QCT/FEA.European radiology · 2021Article
- Finite Element Method for the Evaluation of the Human Spine: A Literature Overview.Journal of functional biomaterials · 2021Review
- Advanced Modeling Methods-Applications to Bone Fracture Mechanics.Current osteoporosis reports · 2020Review
- A Novel Modelling Methodology Which Predicts the Structural Behaviour of Vertebral Bodies under Axial Impact Loading: A Finite Element and DIC Study.Materials (Basel, Switzerland) · 2020Article
- Mechanical testing setups affect spine segment fracture outcomes.Journal of the mechanical behavior of biomedical materials · 2019Article
- A novel technique with reduced computed tomography exposure to predict vertebral compression fracture: a finite element study based on rat vertebrae.Medical & biological engineering & computing · 2019Article
- Quantitative Computed Tomography Protocols Affect Material Mapping and Quantitative Computed Tomography-Based Finite-Element Analysis Predicted Stiffness.Journal of biomechanical engineering · 2016Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Osteoporotic vertebral body fractures are an increasing clinical problem among the aging population. Specimen-specific finite element models, derived from quantitative computed tomography (QCT), have the potential to more accurately predict failure loads in the vertebra. Additionally, the use of extended finite element modeling (X-FEM) allows for a detailed analysis of crack initiation and propagation in various materials. Our aim was to study the feasibility of QCT/X-FEM analysis to predict fracture properties of vertebral bodies. Three cadaveric specimens were obtained, and the L3 vertebrae were excised. The vertebrae were CT scanned to develop computational models and mechanically tested in compression to measure failure load, stiffness and to observe crack location. One vertebra was used for calibration of the material properties from experimental results and CT gray-scale values. The two additional specimens were used to assess the model prediction. The resulting QCT/X-FEM model of the specimen used for calibration had 2 and 4% errors in stiffness and failure load, respectively, compared with the experiment. The predicted failure loads of the additional two vertebrae were larger by about 41-44% when compared to the measured values, while the stiffness differed by 129 and 40%. The predicted fracture patterns matched fairly well with the visually observed experimental cracks. Our feasibility study indicated that the QCT/X-FEM method used to predict vertebral compression fractures is a promising tool to consider in future applications for improving vertebral fracture risk prediction in the elderly.
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