Evidence map›Paper›PMID 26239161›Full record

ArticleScientific reports2015

Visceral fat area is associated with HbA1c but not dialysate-related glucose load in nondiabetic PD patients.

Li-chun Ho, Chung-Jen Yen, Chia-Ter Chao, Chih-Kang Chiang, Jenq-Wen Huang, Kuan-Yu Hung

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. New-Onset Diabetes Mellitus in Peritoneal Dialysis and Hemodialysis Patients: Frequency, Risk Factors, and Prognosis-A Review.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2019
    Review
  5. Observational
  6. Association between Smoking Behavior Patterns and Glycated Hemoglobin Levels in a General Population.International journal of environmental research and public health · 2018
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Li-chun Ho1] Division of Nephrology, Department of Internal Medicine, I-Shou University, E-DA Road, Kaohsiung, Taiwan [2] Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei.
Chung-Jen YenDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei.
Chia-Ter ChaoDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei.
Chih-Kang Chiang1] Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei [2] Department of Internal Medicine, Jin-Shan branch, National Taiwan University Hospital and College of Medicine, New Taipei City, Taiwan.
Jenq-Wen HuangDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei.
Kuan-Yu HungDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei.
National Taiwan University Hospital · TWI-Shou University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Factors associated with increased visceral fat area (VFA) have been well documented in the general population but rarely explored in nondiabetic individuals on peritoneal dialysis (PD). As glycosylated hemoglobin (HbA1c) is positively correlated with VFA in diabetic patients, we hypothesized that the same correlation would exist in nondiabetic PD patients. We enrolled 105 nondiabetic patients who had undergone chronic PD for more than 3 months. Each subject underwent an abdominal computed tomography (CT) scan, and the umbilicus cut was analyzed for VFA. VFA values, corrected for body mass index and subjected to natural logarithm transformations, were examined to determine whether they were correlated with HbA1c and other parameters. PD dialysates prescribed at the time of enrollment were recorded to calculate glucose load. We found that when 105 nondiabetic PD patients were classified according to tertiles of HbA1c, higher HbA1c was associated with larger VFA. Multiple linear regression analysis revealed that HbA1c was an independent determinant of VFA, while glucose load and other PD-specific factors were not. In summary, HbA1c, but not PD-related glucose load, was positively correlated with VFA in nondiabetic PD patients, suggesting clinical utility of HbA1c in the PD population.

Indexed as

Peritoneal DialysisAdultAgedBiomarkersDialysis SolutionsFemaleGlucoseGlycated HemoglobinGlycosylationHumansIntra-Abdominal FatMaleMiddle AgedObesityRenal Insufficiency, ChronicTomography, X-Ray ComputedBiomarkersDialysis SolutionsGlucoseGlycated Hemoglobinhemoglobin A1c protein, human

Identifiers

PMID26239161
PMCPMC4523850
OpenAlexW2406477317

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.