ArticleChembiochem : a European journal of chemical biology2015
Moonlighting Metals: Insights into Regulation of Cyclization Pathways in Fungal Δ(6) -Protoilludene Sesquiterpene Synthases.
Article in Chembiochem : a European journal of chemical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Molecular and Functional Analyses of Characterized Sesquiterpene Synthases in Mushroom-Forming Fungi.Journal of fungi (Basel, Switzerland) · 2023Article
- Overview of fungal terpene synthases and their regulation.World journal of microbiology & biotechnology · 2023Review
- A Sesquiterpene Synthase from the Endophytic FungusBiomolecules · 2021Article
- Expression of the Fusarium graminearum terpenome and involvement of the endoplasmic reticulum-derived toxisome.Fungal genetics and biology : FG & B · 2019Article
- New terpenoids from the fermentation broth of the edible mushroomBeilstein journal of organic chemistry · 2019Article
- Genome of Diaporthe sp. provides insights into the potential inter-phylum transfer of a fungal sesquiterpenoid biosynthetic pathway.Fungal biology · 2016Article
- Biocatalytic portfolio of Basidiomycota.Current opinion in chemical biology · 2016Review
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Abstract
Fungal 1,11 cyclizing sesquiterpene synthases are product specific under typical reaction conditions. However, in vivo expression of certain Δ(6)-protoilludene synthases results in dual 1,11 and 1,10 cyclization. To determine the factors regulating this mechanistic variation, in-depth in vitro characterization of Δ(6)-protoilludene synthases was conducted. Divalent metal ions determine cyclization specificity and this product variability. Promiscuity in metal binding is mediated by secondary metal-binding sites away from the conserved D(D/E)XX(D/E) motif in sesquiterpene synthases. Phylogenetic analysis revealed a divergent evolution of Basidiomycota trans-humulyl cation producing sesquiterpene synthases, results that indicate a wider diversity in function than previously predicted. This study provides key insights into the function and evolution of 1,11 cyclizing fungal sesquiterpene synthases.
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