ArticleInternational journal of obesity (2005)2015
A novel gene THSD7A is associated with obesity.
Article in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Unique attributes of obesity in India: A narrative review.Obesity medicine · 2022Article
- Article
- Correlation Between THSD7A Expression and Tumor Characteristics of Azoxymethane-Induced Colon Cancer Model in Rats.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- Angiogenic Potential, Circulating Angiogenic Factors and Insulin Resistance in Subjects with Obesity.Indian journal of clinical biochemistry : IJCB · 2021Article
- Estimating the Prevalence and Genetic Risk Mechanisms of ARFID in a Large Autism Cohort.Frontiers in psychiatry · 2021Article
- Pilot GWAS of caries in African-Americans shows genetic heterogeneity.BMC oral health · 2019Article
- WWOX somatic ablation in skeletal muscles alters glucose metabolism.Molecular metabolism · 2019Article
- Expression, prognosis and functional role of Thsd7a in esophageal squamous cell carcinoma of Kazakh patients, Xinjiang.Oncotarget · 2017Article
- Reply to 'Lack of replication of association of THSD7A with obesity'.International journal of obesity (2005) · 2016Article
- Lack of replication of association of THSD7A with obesity.International journal of obesity (2005) · 2016Article
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24 authors at 7 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Body mass index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian populations are admixture of two ancestral populations; ancestral north Indians (ANI) and ancestral south Indians (ASI). Although ANI are related to Europeans, ASI are not related to any group outside Indian-subcontinent. Hence, we expect novel genetic loci associated with BMI. In association analysis, we found eight genic SNPs in extreme of distribution (P⩽3.75 × 10(-5)), of which WWOX has already been reported to be associated with obesity-related traits hence excluded from further study. Interestingly, we observed rs1526538, an intronic SNP of THSD7A; a novel gene significantly associated with obesity (P=2.88 × 10(-5), 8.922 × 10(-6) and 2.504 × 10(-9) in discovery, replication and combined stages, respectively). THSD7A is neural N-glycoprotein, which promotes angiogenesis and it is well known that angiogenesis modulates obesity, adipose metabolism and insulin sensitivity, hence our result find a correlation. This information can be used for drug target, early diagnosis of obesity and treatment.
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