ArticleInfection and immunity2015
Toll-Like Receptor 9 Contributes to Defense against Acinetobacter baumannii Infection.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
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- Virulence Factors and Pathogenicity Mechanisms ofAntibiotics (Basel, Switzerland) · 2023Review
- Deciphering the virulence factors, regulation, and immune response toFrontiers in cellular and infection microbiology · 2023Review
- Bacterial Community Characteristics Shaped by Artificial Environmental PM2.5 Control in Intensive Broiler Houses.International journal of environmental research and public health · 2022Article
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- Proteomics Landscape of Host-Pathogen Interaction inFrontiers in genetics · 2021Article
- Cathelicidin-related Antimicrobial Peptide Contributes to Host Immune Responses Against Pulmonary Infection withImmune network · 2020Article
- Broad-spectrum suppression of bacterial pneumonia by aminoglycoside-propagated Acinetobacter baumannii.PLoS pathogens · 2020Article
- Transcriptome Profiling of Lung Innate Immune Responses Potentially Associated With the Pathogenesis ofFrontiers in immunology · 2020Article
- Host Innate Immune Responses toFrontiers in cellular and infection microbiology · 2020Review
- Analysis of Immune Responses inFrontiers in immunology · 2020Article
- Innate Immune Responses toJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2019Review
- Anti-Bacterial Effect of CpG-DNA Involves Enhancement of the Complement Systems.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Acinetobacter baumannii is a common nosocomial pathogen capable of causing severe diseases associated with significant morbidity and mortality in impaired hosts. Pattern recognition receptors, such as the Toll-like receptors (TLRs), play a key role in pathogen detection and function to alert the immune system to infection. Here, we examine the role for TLR9 signaling in response to A. baumannii infection. In a murine model of A. baumannii pneumonia, TLR9(-/-) mice exhibit significantly increased bacterial burdens in the lungs, increased extrapulmonary bacterial dissemination, and more severe lung pathology compared with those in wild-type mice. Following systemic A. baumannii infection, TLR9(-/-) mice have significantly increased bacterial burdens in the lungs, as well as decreased proinflammatory cytokine and chemokine production. These results demonstrate that TLR9-mediated pathogen detection is important for host defense against the opportunistic pathogen Acinetobacter baumannii.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.