ArticleNature communications2015
Rescue of long-term memory after reconsolidation blockade.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Aging disrupts transcriptional programs for memory updating in the dorsal hippocampus and reveals a required role forbioRxiv : the preprint server for biology · 2026Article
- PKMζ drives spatial memory reconsolidation but not maintenance.Frontiers in synaptic neuroscience · 2025Article
- Beyond reconsolidation: The need for a broad theoretical approach in clinical translations of research on retrieval-induced plasticity.Behavioral neuroscience · 2024Review
- Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse.Translational psychiatry · 2023Article
- Spatial contextual recognition memory updating is modulated by dopamine release in the dorsal hippocampus from the locus coeruleus.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity.Acta physiologica (Oxford, England) · 2022Review
- Covert capture and attenuation of a hippocampus-dependent fear memory.Nature neuroscience · 2021Article
- Mechanisms of Memory Updating: State Dependency vs. Reconsolidation.Journal of cognition · 2021Article
- Limited replicability of drug-induced amnesia after contextual fear memory retrieval in rats.Neurobiology of learning and memory · 2019Article
- Recognition memory reconsolidation requires hippocampal Zif268.Scientific reports · 2019Article
- Susceptibility of consolidated procedural memory to interference is independent of its active task-based retrieval.PloS one · 2019Article
- Regulation of the Expression of the Psychiatric Risk GeneMolecular neuropsychiatry · 2018Article
- Novelty enhances memory persistence and remediates propranolol-induced deficit via reconsolidation.Neuropharmacology · 2018Article
- Transcriptional Regulation Involved in Fear Memory Reconsolidation.Journal of molecular neuroscience : MN · 2018Review
- The Neurogenesis Actuator and NR2B/NMDA Receptor Antagonist Ro25-6981 Consistently Improves Spatial Memory Retraining Via Brain Region-Specific Gene Expression.Journal of molecular neuroscience : MN · 2018Article
- The effect of ketamine on the consolidation and extinction of contextual fear memory.Journal of psychopharmacology (Oxford, England) · 2018Article
- Re-stepping into the same river: competition problem rather than a reconsolidation failure in an established motor skill.Scientific reports · 2017Article
- AMPA receptors control fear extinction through an Arc-dependent mechanism.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- An Update on Memory Reconsolidation Updating.Trends in cognitive sciences · 2017Review
- Prevention of long-term memory loss after retrieval by an endogenous CaMKII inhibitor.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Memory reconsolidation is considered to be the process whereby stored memories become labile on recall, allowing updating. Blocking the restabilization of a memory during reconsolidation is held to result in a permanent amnesia. The targeted knockdown of either Zif268 or Arc levels in the brain, and inhibition of protein synthesis, after a brief recall results in a non-recoverable retrograde amnesia, known as reconsolidation blockade. These experimental manipulations are seen as key proof for the existence of reconsolidation. However, here we demonstrate that despite disrupting the molecular correlates of reconsolidation in the hippocampus, rodents are still able to recover contextual memories. Our results challenge the view that reconsolidation is a separate memory process and instead suggest that the molecular events activated initially at recall act to constrain premature extinction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.