ArticleDevelopmental biology2015
Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- Evolutionary pathway and genetic mechanisms of fin-to-limb transition in vertebrates.Frontiers in cell and developmental biology · 2026Review
- Caudal fin shape imprinted during late zebrafish embryogenesis is re-patterned by the Sonic hedgehog pathway.PLoS biology · 2025Article
- Pathogenic variants in SHROOM3 associated with hemifacial microsomia.Journal of human genetics · 2025Article
- Article
- Identification and characterization of Hand2 upstream genomic enhancers active in developing stomach and limbs.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.Developmental biology · 2023Article
- The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.bioRxiv : the preprint server for biology · 2023Article
- CDON contributes to Hedgehog-dependent patterning and growth of the developing limb.Developmental biology · 2023Article
- Timing is everything: Transcriptional repression is not the default mode for regulating Hedgehog signaling.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Article
- A limb bud morphogen bites the dust.Developmental cell · 2022Article
- Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice.Developmental cell · 2022Article
- Comprehensive expression analysis for the core cell cycle regulators in the chicken embryo reveals novel tissue-specific synexpression groups and similarities and differences with expression in mouse, frog and zebrafish.Journal of anatomy · 2022Article
- Dia1 coordinates differentiation and cell sorting in a stratified epithelium.The Journal of cell biology · 2022Article
- Article
- HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly.PLoS genetics · 2021Article
- Paternal preconception phthalate exposure alters sperm methylome and embryonic programming.Environment international · 2021Article
- Induction and expansion of human PRRX1Nature biomedical engineering · 2021Article
- Variant type and position predict two distinct limb phenotypes in patients with GLI3-mediated polydactyly syndromes.Journal of medical genetics · 2021Article
- β-catenin in adrenal zonation and disease.Molecular and cellular endocrinology · 2021Review
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
GLI proteins convert Sonic hedgehog (Shh) signaling into a transcriptional output in a tissue-specific fashion. The Shh pathway has been extensively studied in the limb bud, where it helps regulate growth through a SHH-FGF feedback loop. However, the transcriptional response is still poorly understood. We addressed this by determining the gene expression patterns of approximately 200 candidate GLI-target genes and identified three discrete SHH-responsive expression domains. GLI-target genes expressed in the three domains are predominately regulated by derepression of GLI3 but have different temporal requirements for SHH. The GLI binding regions associated with these genes harbor both distinct and common DNA motifs. Given the potential for interaction between the SHH and FGF pathways, we also measured the response of GLI-target genes to inhibition of FGF signaling and found the majority were either unaffected or upregulated. These results provide the first characterization of the spatiotemporal response of a large group of GLI-target genes and lay the foundation for a systems-level understanding of the gene regulatory networks underlying SHH-mediated limb patterning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.