Evidence map›Paper›PMID 26238356›Full record

ReviewCold Spring Harbor perspectives in biology2015

The opposing actions of target of rapamycin and AMP-activated protein kinase in cell growth control.

Sravanth K Hindupur, Asier González, Michael N Hall

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 148 citations in OpenAlex.

  1. Trial
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  10. Di-Food science & nutrition · 2025
    Article
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  13. Mitochondrial Measures in Primary Cells Isolated from Patients with ME/CFS.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sravanth K HindupurBiozentrum, University of Basel, CH4056 Basel, Switzerland.
Asier GonzálezBiozentrum, University of Basel, CH4056 Basel, Switzerland.
Michael N HallBiozentrum, University of Basel, CH4056 Basel, Switzerland.
University of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell growth is a highly regulated, plastic process. Its control involves balancing positive regulation of anabolic processes with negative regulation of catabolic processes. Although target of rapamycin (TOR) is a major promoter of growth in response to nutrients and growth factors, AMP-activated protein kinase (AMPK) suppresses anabolic processes in response to energy stress. Both TOR and AMPK are conserved throughout eukaryotic evolution. Here, we review the fundamentally important roles of these two kinases in the regulation of cell growth with particular emphasis on their mutually antagonistic signaling.

Indexed as

AMP-Activated Protein KinasesAnimalsCell DivisionHumansSaccharomyces cerevisiaeSignal TransductionTOR Serine-Threonine KinasesAMP-Activated Protein KinasesTOR Serine-Threonine Kinases

Identifiers

PMID26238356
PMCPMC4526743
OpenAlexW1830885889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.