Evidence map›Paper›PMID 26238235›Full record

ArticleProstate cancer and prostatic diseases2015

Genetic variants in the TEP1 gene are associated with prostate cancer risk and recurrence.

C Gu, Q Li, Y Zhu, Y Qu, G Zhang, M Wang, Y Yang, J Wang, L Jin, Q Wei and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Prostate cancer and prostatic diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. The Influence ofJournal of clinical medicine · 2023
    Article
  2. Article
  3. Article
  4. Genetic variants inJournal of Cancer · 2019
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

C GuDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Q LiDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Y ZhuDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Y QuDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
G ZhangDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
M WangDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Y YangMinistry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
J WangMinistry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
L JinMinistry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Q WeiCancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
D YeDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Shanghai Medical College of Fudan University · CNFudan University · CNDuke Medical Center · USFudan University Shanghai Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTelomere-related genes play an important role in carcinogenesis and progression of prostate cancer (PCa). It is not fully understood whether genetic variations in telomere-related genes are associated with development and progression in PCa patients.

methodsSix potentially functional single-nucleotide polymorphisms (SNPs) of three key telomere-related genes were evaluated in 1015 PCa cases and 1052 cancer-free controls, to test their associations with risk of PCa. Among 426 PCa patients who underwent radical prostatectomy (RP), the prognostic significance of the studied SNPs on biochemical recurrence (BCR) was also assessed using the Kaplan-Meier analysis and Cox proportional hazards regression model. The relative telomere lengths (RTLs) were measured in peripheral blood leukocytes using real-time PCR in the RP patients.

resultsTEP1 rs1760904 AG/AA genotypes were significantly associated with a decreased risk of PCa (odds ratio (OR): 0.77, 95% confidence interval (CI): 0.64-0.93, P=0.005) compared with the GG genotype. By using median RTL as a cutoff level, RP patients with TEP1 rs1760904 AG/AA genotypes tended to have a longer RTL than those with the GG genotype (OR: 1.55, 95% CI: 1.04-2.30, P=0.031). A significant interaction between TEP1 rs1713418 and age in modifying PCa risk was observed (P=0.005). After adjustment for clinicopathologic risk factors, the presence of heterozygotes or rare homozygotes of TEP1 rs1760904 and TNKS2 rs1539042 were associated with BCR in the RP cohorts (hazard ratio: 0.53, 95% CI: 0.36-0.79, P=0.002 and hazard ratio: 1.67, 95% CI: 1.07-2.48, P=0.017, respectively).

conclusionsThese data suggest that genetic variations in the TEP1 gene may be biomarkers for risk of PCa and BCR after RP.

Indexed as

Gene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseGenetic VariationAdultAgedAged, 80 and overAllelesCarrier ProteinsCase-Control StudiesGene FrequencyGenotypeHumansMaleMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalCarrier ProteinsRNA-Binding ProteinsTankyrasesTEP1 protein, humanTNKS2 protein, humanTNKS protein, human

Identifiers

PMID26238235
OpenAlexW1944679183

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.