ArticleMolecular medicine reports2015
Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays.
Article in Molecular medicine reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Review on melanosis coli and anthraquinone-containing traditional Chinese herbs that cause melanosis coli.Frontiers in pharmacology · 2023Review
- Article
- Severe grade of melanosis coli is associated with a higher detection rate of colorectal adenoma.Journal of clinical biochemistry and nutrition · 2022Article
- Melanosis Coli Due to Aloe Vera Consumption.Internal medicine (Tokyo, Japan) · 2020Article
- Comparison between Diffusion-Weighted Sequences with Selective and Non-Selective Fat Suppression in the Evaluation of Crohn's Disease Activity: Are They Equally Useful?Diagnostics (Basel, Switzerland) · 2020Article
- Severe chronic bowel obstruction associated with brown bowel syndrome.SAGE open medical case reports · 2020Article
- Gender, age, and concomitant diseases of melanosis coli in China: a multicenter study of 6,090 cases.PeerJ · 2018Article
- Disappearance of Melanosis Coli After Administration of IVIG.The American journal of gastroenterology · 2017Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanosis coli (MC) refers to the condition characterized by abnormal brown or black pigmentation deposits on the colonic mucosa. However, the histopathological findings and genes associated with the pathogenesis of melanosis coli remain to be fully elucidated. The present study aimed to examine the histopathological features and differentially expressed genes of MC. This involved performing hematoxylin and eosin staining, specific staining and immunohistochemistry on tissues sections, which were isolated from patients diagnosed with MC. DNA expression microarray analysis, western blotting and immunofluorescence assays were performed to analyze the differentially expressed genes of melanosis coli. The results demonstrated that the pigment deposits in MC consisted of lipofuscin. A TUNEL assay revealed that a substantial number of apoptotic cells were present within the macrophages and superficial lamina propria of the colonic epithelium. Expression microarray analysis revealed that the significantly downregulated genes were CYP3A4, CYP3A7, UGT2B11 and UGT2B15 in melanosis coli. Western blotting and immunofluorescence assays indicated that the expression of CYP3A4 in the normal tissue was higher than in the MC tissue. The results of the present study provided a comprehensive description of the histopathological characteristics and pathogenesis of MC and for the first time, to the best of our knowledge, demonstrated that the cytochrome P450‑associated genes were significantly downregulated in melanosis coli. This novel information can be used to assist in further investigations of melanosis coli.
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