ArticleJournal of clinical medicine2014
Neurosurgical Hyponatremia.
Article in Journal of clinical medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Pediatric osmotic demyelination syndrome triggered by post-traumatic pituitary stalk injury: a case report.BMC pediatrics · 2026Article
- Hyponatremia Following Endoscopic Third Ventriculostomy in an Adolescent with an Aqueductal Web: A Case Report.Reports (MDPI) · 2026Article
- Article
- A Contemporary Narrative Review of Sodium Homeostasis Mechanisms, Dysnatraemia, and the Clinical Relevance in Adult Critical Illness.Journal of clinical medicine · 2025Review
- Dynamic sodium dysregulation predicts mortality in intracerebral hemorrhage: A retrospective cohort study of temporal variability and absolute thresholds.Neurosurgical review · 2025Article
- Role of oxidative/nitrosative stress in dysfunction of rat's intracerebral parenchymal arterioles in low sodium environment in the presence of vasopressin.Pflugers Archiv : European journal of physiology · 2025Article
- The U-shaped relationship between serum osmolality and in-hospital mortality in patients with traumatic brain injury: a retrospective study based on the MIMIC-IV database.European journal of medical research · 2025Article
- Electrolyte Imbalance in Acute Traumatic Brain Injury: Insights from the First 24 h.Clinics and practice · 2024Article
- Association between postoperative changes in natremia and outcomes in patients undergoing elective craniotomy.Neurosurgical review · 2024Article
- Relationship between sodium level and in-hospital mortality in traumatic brain injury patients of MIMIC IV database.Frontiers in neurology · 2024Article
- Spontaneous brainstem haemorrhage in a patient with uraemia undergoing initial hemodialysis: A case report.Experimental and therapeutic medicine · 2023Article
- Safety, Precautions, and Modalities in Cancer Rehabilitation: an Updated Review.Current physical medicine and rehabilitation reports · 2021Review
- Risk factors and predictive model of adrenocortical insufficiency in patients with traumatic brain injury.World journal of emergency medicine · 2021Article
- Non-functioning pituitary adenomas: indications for pituitary surgery and post-surgical management.Pituitary · 2019Review
- Inappropriate Antidiuretic Hormone Secretion and Cerebral Salt-Wasting Syndromes in Neurological Patients.Frontiers in neuroscience · 2019Review
- A practical method for prevention of readmission for symptomatic hyponatremia following transsphenoidal surgery.Pituitary · 2018Article
- A Case of Delayed-Onset Posthypoxic Leukoencephalopathy in a Pediatric Patient.Child neurology open · 2018Article
- Treatment of Hyponatremia with Tolvaptan in a Patient after Neurosurgical Treatment of a Pituitary Tumor: Case Report and Review of Literature.Journal of neurological surgery reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyponatremia is a frequent electrolyte imbalance in hospital inpatients. Acute onset hyponatremia is particularly common in patients who have undergone any type of brain insult, including traumatic brain injury, subarachnoid hemorrhage and brain tumors, and is a frequent complication of intracranial procedures. Acute hyponatremia is more clinically dangerous than chronic hyponatremia, as it creates an osmotic gradient between the brain and the plasma, which promotes the movement of water from the plasma into brain cells, causing cerebral edema and neurological compromise. Unless acute hyponatremia is corrected promptly and effectively, cerebral edema may manifest through impaired consciousness level, seizures, elevated intracranial pressure, and, potentially, death due to cerebral herniation. The pathophysiology of hyponatremia in neurotrauma is multifactorial, but most cases appear to be due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Classical treatment of SIADH with fluid restriction is frequently ineffective, and in some circumstances, such as following subarachnoid hemorrhage, contraindicated. However, the recently developed vasopressin receptor antagonist class of drugs provides a very useful tool in the management of neurosurgical SIADH. In this review, we summarize the existing literature on the clinical features, causes, and management of hyponatremia in the neurosurgical patient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.