Evidence map›Paper›PMID 26237428›Full record

SynthesisNature genetics2015

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.

Matthew H Law, D Timothy Bishop, Jeffrey E Lee, Myriam Brossard, Nicholas G Martin, Eric K Moses, Fengju Song, Jennifer H Barrett, Rajiv Kumar, Douglas F Easton and 71 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 15 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 15 syntheses or guidelines pooled it, 240 citations in OpenAlex.

  1. Pooled it
  2. Systematic review on gene-sun exposure interactions in skin cancer.Molecular genetics & genomic medicine · 2023
    Pooled it
  3. Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.Movement disorders : official journal of the Movement Disorder Society · 2023
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  17. Genetic Variation in Steroid and Xenobiotic Metabolizing Pathways and Enterolactone Excretion Before and After Flaxseed Intervention in African American and European American Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019
    Trial
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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

81 authors at 20 institutions in 16 countries.

Matthew H LawStatistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
D Timothy BishopSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Jeffrey E Lee *Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Myriam Brossard *Institut National de la Santé et de la Recherche Médicale (INSERM), UMR-946, Genetic Variation and Human Diseases Unit, Paris, France.
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Eric K MosesCentre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, Western Australia, Australia.
Fengju SongDepartments of Epidemiology and Biostatistics, Key Laboratory of Cancer Prevention and Therapy, Tianjin, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P. R. China.
Jennifer H BarrettSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Rajiv KumarDivision of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, Heidelberg Germany.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Katerina P KypreouDepartment of Dermatology, University of Athens School of Medicine, Andreas Sygros Hospital, Athens, Greece.
John C TaylorSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Mark HarlandSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Juliette Randerson-MoorSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Lars A AkslenCentre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Per A AndresenDepartment of Pathology, Molecular Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Marie-Françoise AvrilAssistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes, Paris, France.
Esther AziziDepartment of Dermatology, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv, Israel.
Giovanna Bianchi ScarràDepartment of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.
Kevin M BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Tadeusz DębniakInternational Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
David L DuffyGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
David E ElderDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Shenying FangDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Eitan FriedmanOncogenetics Unit, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Pilar GalanUniversité Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Institut National de la Santé et de la Recherche Médicale (INSERM U1153), Institut National de la Recherche Agronomique (INRA U1125), Conservatoire National des Arts et Métiers, Communauté d'Université Sorbonne Paris Cité, F-93017 Bobigny, France.
Paola GhiorzoDepartment of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.
Elizabeth M GillandersInherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, USA.
Alisa M GoldsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Nelleke A GruisDepartment of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands.
Johan HanssonDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Per HelsingDepartment of Dermatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Marko HočevarDepartment of Surgical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Veronica HöiomDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Christian IngvarDepartment of Surgery, Clinical Sciences, Lund University, Lund, Sweden.
Peter A KanetskyDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Wei V ChenDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
GenoMEL Consortium
Essen-Heidelberg Investigators
SDH Study Group
Q-MEGA and QTWIN Investigators
AMFS Investigators
ATHENS Melanoma Study Group
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Julie LangDepartment of Medical Genetics, University of Glasgow, Glasgow, UK.
G Mark LathropMcGill University and Genome Quebec Innovation Centre, Montreal, Canada.
Jan LubińskiInternational Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Rona M MackieDepartment of Public Health, University of Glasgow, Glasgow UK.
Graham J MannCentre for Cancer Research, University of Sydney at Westmead, Millennium Institute for Medical Research and Melanoma Institute Australia, Sydney, Australia.
Anders MolvenDepartment of Pathology, Haukeland University Hospital, Bergen, Norway.
Grant W MontgomeryMolecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Srdjan NovakovićDepartment of Molecular Diagnostics, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Håkan OlssonDepartment of Oncology/Pathology, Clinical Sciences, Lund University, Lund; Sweden.
Susana PuigMelanoma Unit, Dermatology Department & Biochemistry and Molecular Genetics Departments, Hospital Clinic, Institut de Investigacó Biomèdica August Pi Suñe, Universitat de Barcelona, Barcelona, Spain.
Joan Anton Puig-ButilleMelanoma Unit, Dermatology Department & Biochemistry and Molecular Genetics Departments, Hospital Clinic, Institut de Investigacó Biomèdica August Pi Suñe, Universitat de Barcelona, Barcelona, Spain.
Abrar A QureshiDepartment of Dermatology, The Warren Alpert Medical School of Brown University, Rhode Island, USA.
Graham L Radford-SmithInflammatory Bowel Diseases, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Nienke van der StoepDepartment of Clinical Genetics, Center of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Remco van DoornDepartment of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands.
David C WhitemanCancer Control Group, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Jamie E CraigDepartment of Ophthalmology, Flinders University, Adelaide, Australia.
Dirk SchadendorfDepartment of Dermatology, University Hospital Essen, Essen, Germany.
Lisa A SimmsInflammatory Bowel Diseases, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Kathryn P BurdonMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Dale R NyholtInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Karen A PooleyCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Nick OrrBreakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Alexander J StratigosDepartment of Dermatology, University of Athens School of Medicine, Andreas Sygros Hospital, Athens, Greece.
Anne E CustCancer Epidemiology and Services Research, Sydney School of Public Health, The University of Sydney, Australia.
Sarah V WardCentre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, Western Australia, Australia.
Nicholas K HaywardOncogenomics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Jiali HanDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA.
Hans-Joachim SchulzeDepartment of Dermatology, Fachklinik Hornheide, Institute for Tumors of the Skin at the University of Münster, Münster, Germany.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Julia A Newton BishopSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Florence Demenais *Institut National de la Santé et de la Recherche Médicale (INSERM), UMR-946, Genetic Variation and Human Diseases Unit, Paris, France.
Christopher I Amos *Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Stuart MacGregorStatistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Mark M IlesSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
QIMR Berghofer Medical Research Institute · AUUniversity of Leeds · GBInserm · FRNational Institutes of Health · USThe University of Sydney · AUHaukeland University Hospital · NOLund University · SENational and Kapodistrian University of Athens · GRThe University of Texas MD Anderson Cancer Center · USDartmouth College · USFlinders University · AUInstitute of Cancer Research · GBInstitute of Oncology Ljubljana · SIInternational Hereditary Cancer Center · PLIstituti di Ricovero e Cura a Carattere Scientifico · ITKarolinska University Hospital · SELeiden University Medical Center · NLOslo University Hospital · NOQueensland University of Technology · AUTel Aviv University · IL

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
UT M.D. Anderson Cancer Center SPORE in MelanomaP50CA093459 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GRIMM, ELIZABETH A · 2004 to 2014
$23.7M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Genetic Epidermiology of MelanomaR01CA083115 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BISHOP, DAVID TIMOTHY, ELDER, DAVID ERIC · 2001 to 2017
$13.0M
Pathways from genotype and environment to melanomaR01CA088363 · NCI · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI HAYWARD, NICHOLAS K · 2001 to 2012
$2.4M
Genetic Predictors for DNA Repair Phenotype in CMMR01CA100264 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2004 to 2008
$1.5M
Cohort Study of Genetic Susceptibility to Cutaneous Malignant MelanomaR01CA122838 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HAN, JIALI · 2008 to 2010
$1.4M
Statistical Methods for Gene Environment Interactions In Lung CancerR01CA133996 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I. · 2007 to 2009
$790k
Integrating Genetics of Gene Expression into Pathway Analysis for Melanoma GWASR03CA167741 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI HAN, JIALI · 2012 to 2013
$189k
Cancer Research UK 10124Cancer Research UK 10589Cancer Research UK 16561Cancer Research UK 16565Cancer Research UK 19167Cancer Research UK A10589Cancer Research UK A4994Medical Research Council MR/L01629X/1NCATS NIH HHS UL1 TR001108NCI NIH HHS P30 CA023108NCI NIH HHS P50 CA093459NCI NIH HHS R01 CA083115NCI NIH HHS R01 CA088363NCI NIH HHS R01 CA100264NCI NIH HHS R01 CA122838NCI NIH HHS R01 CA133996NCI NIH HHS R03 CA167741Wellcome Trust
6 · The paper itself

Abstract

Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10(-8)), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.

Indexed as

Case-Control StudiesChromosomes, HumanCutaneous Malignant MelanomaGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMelanomaPolymorphism, Single NucleotideSkin Neoplasms

Identifiers

PMID26237428
PMCPMC4557485
OpenAlexW1916780560

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.