ArticleNature neuroscience2015
Naturalistic stimulation drives opposing heterosynaptic plasticity at two inputs to songbird cortex.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Cholinergic signaling differentially regulates a vocal motor pallial nucleus to stabilize adult birdsong.Communications biology · 2026Article
- Variable and slow-paced neural dynamics in HVC underlie plastic song production in juvenile zebra finches.BMC neuroscience · 2024Article
- Performance-Dependent Consolidation of Learned Vocal Changes in Adult Songbirds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Thalamocortical contribution to flexible learning in neural systems.Network neuroscience (Cambridge, Mass.) · 2022Article
- Plasticity of stereotyped birdsong driven by chronic manipulation of cortical-basal ganglia activity.Current biology : CB · 2021Article
- Variable but not random: temporal pattern coding in a songbird brain area necessary for song modification.Journal of neurophysiology · 2021Article
- Synaptic plasticity rules with physiological calcium levels.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Brain-Derived Neurotrophic Factor Has a Transsynaptic Trophic Effect on Neural Activity in an Adult Forebrain Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry.eLife · 2019Article
- Variation in sequence dynamics improves maintenance of stereotyped behavior in an example from bird song.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Vocal learning in songbirds requires cholinergic signaling in a motor cortex-like nucleus.Journal of neurophysiology · 2018Article
- Vocal practice regulates singing activity-dependent genes underlying age-independent vocal learning in songbirds.PLoS biology · 2018Article
- Bidirectional scaling of vocal variability by an avian cortico-basal ganglia circuit.Physiological reports · 2018Article
- Modulation of Spike-Timing Dependent Plasticity: Towards the Inclusion of a Third Factor in Computational Models.Frontiers in computational neuroscience · 2018Review
- Vocal learning promotes patterned inhibitory connectivity.Nature communications · 2017Article
- Article
- Unsupervised Learning in an Ensemble of Spiking Neural Networks Mediated by ITDP.PLoS computational biology · 2016Article
- Carbachol-Induced Reduction in the Activity of Adult Male Zebra Finch RA Projection Neurons.Neural plasticity · 2016Article
- Naturalistic stimulation changes the dynamic response of action potential encoding in a mechanoreceptor.Frontiers in physiology · 2015Article
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Authors and funding
2 authors.
Funding
Abstract
Songbirds learn precisely sequenced motor skills (songs) subserved by distinct brain areas, including the premotor cortical analog HVC, which is essential for producing learned song, and a 'cortical'-basal ganglia loop required for song plasticity. Inputs from these nuclei converge in RA (robust nucleus of the arcopallium), making it a likely locus for song learning. However, activity-dependent synaptic plasticity has never been described in either input. Using a slice preparation, we found that stimulation patterns based on singing-related activity were able to drive opposing changes in the strength of RA's inputs: when one input was potentiated, the other was depressed, with the direction and magnitude of changes depending on the relative timing of stimulation of the inputs. Moreover, pharmacological manipulations that blocked synaptic plasticity in vitro also prevented reinforcement-driven changes to song in vivo. Together, these findings highlight the importance of precise timing in the basal ganglia-motor cortical interactions subserving adaptive motor skills.
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