ArticlePloS one2015
Serum Cardiac Troponin-I is Superior to Troponin-T as a Marker for Left Ventricular Dysfunction in Clinically Stable Patients with End-Stage Renal Disease.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Clinical Gray Zones of Cardiac Troponin Interpretation in the Emergency Department: When Increased Concentrations Do Not Equal Acute Coronary Syndrome.Journal of clinical medicine · 2026Review
- Cardiac troponin patterns in athletes completing Norseman Xtreme Triathlon.BMJ open sport & exercise medicine · 2026Article
- The Pathophysiology of Cardiac Troponin Release and the Various Circulating Cardiac Troponin Forms-Potential Clinical Implications.Journal of clinical medicine · 2025Review
- Cardiac Troponin Levels in Patients with Chronic Kidney Disease: "Markers of High Risk or Just Noise''?Diagnostics (Basel, Switzerland) · 2024Review
- Coronary Artery Disease in Patients Undergoing Hemodialysis: A Problem that Sounds the Alarm.Reviews in cardiovascular medicine · 2024Review
- Superiority of high sensitivity cardiac troponin I over NT-proBNP and adiponectin for 7-year mortality in stable patients receiving haemodialysis.Scientific reports · 2024Article
- The association between higher cardiac troponin levels and the development of left ventricular diastolic dysfunction in septic patients with diabetes mellitus.The international journal of cardiovascular imaging · 2024Article
- Article
- Prognostic values of high sensitivity cardiac troponin T and I for long-term mortality in hemodialysis patients.Scientific reports · 2022Article
- Relationships Between Arterial Pressure-Volume Index and Cardiovascular Disease Biomarkers in Patients With Hypertension.Journal of clinical medicine research · 2022Article
- Routinely measured cardiac troponin I and N-terminal pro-B-type natriuretic peptide as predictors of mortality in haemodialysis patients.ESC heart failure · 2022Article
- The ratio of cardiac troponin T to troponin I may indicate non-necrotic troponin release among COVID-19 patients.Clinica chimica acta; international journal of clinical chemistry · 2022Observational
- High-sensitivity troponins in dialysis patients: variation and prognostic value.Clinical kidney journal · 2021Article
- Prognostic value of high-sensitive cardiac troponin I in asymptomatic chronic hemodialysis patients.Journal of nephrology · 2020Article
- Comparison of prognostic ability of perioperative myocardial biomarkers in acute type A aortic dissection.Medicine · 2019Article
- [A review on the clinical application of high-sensitivity cardiac troponin T in neonatal diseases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Review
- Prognostic implications of statin intolerance in stable coronary artery disease patients with different levels of high-sensitive troponin.BMC cardiovascular disorders · 2019 · on this mapObservational
- Associations of sensitive cardiac troponin-I with left ventricular morphology, function and prognosis in end-stage renal disease patients with preserved ejection fraction.Heart and vessels · 2018Article
- Observational
- Relationships between the arterial velocity pulse index as a novel marker of atherosclerosis and biomarkers of cardiac or renal condition in patients with type 2 diabetes mellitus.Diabetology international · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum troponin assays, widely used to detect acute cardiac ischemia, might be useful biomarkers to detect chronic cardiovascular disease (CVD). Cardiac-specific troponin-I (cTnI) and troponin-T (cTnT) generally detect myocardial necrosis equally well. In dialysis patients however, serum cTnT levels are often elevated, unlike cTnI levels. The present study aims to elucidate the associations of cTnI and cTnT with CVD in clinically stable dialysis patients.
methodsTroponin levels were measured using 5th generation hs-cTnT assays (Roche) and STAT hs-cTnI assays (Abbott) in a cohort of dialysis patients. Serum troponin levels were divided into tertiles with the lowest tertile as a reference value. Serum troponins were associated with indicators of CVD such as left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF) and the presence of coronary artery disease (CAD). Associations were explored using regression analysis.
resultsWe included 154 consecutive patients, 68±7 years old, 77% male, 70% hemodialysis. Median serum cTnT was 51ng/L (exceeding the 99th percentile of the healthy population in 98%) and median serum cTnI was 13ng/L (elevated in 20%). A high cTnI (T3) was significantly associated with a higher LVMI (Beta 31.60; p=0.001) and LVEF (Beta -4.78; p=0.005) after adjusting for confounders whereas a high serum cTnT was not. CAD was significantly associated with a high cTnT (OR 4.70 p=0.02) but not with a high cTnI. Unlike cTnI, cTnT was associated with residual renal function (Beta:-0.09; p=0.006).
conclusionIn the present cohort, serum cTnI levels showed a stronger association with LVMI and LVEF than cTnT. However, cTnT was significantly associated with CAD and residual renal function, unlike cTnI. Therefore, cTnI seems to be superior to cTnT as a marker of left ventricular dysfunction in asymptomatic dialysis patients, while cTnT might be better suited to detect CAD in these patients.
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