ArticlePloS one2015
Dexmedetomidine Reduces Shivering during Mild Hypothermia in Waking Subjects.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Subarachnoid and epidural dexmedetomidine for the prevention of post-anesthetic shivering: a meta-analysis and systematic review.Drug design, development and therapy · 2019Pooled it
- The Implementation of Targeted Temperature Management: An Evidence-Based Guideline from the Neurocritical Care Society.Neurocritical care · 2017Pooled it
- Glycopyrrolate does not ameliorate hypothermia associated bradycardia in healthy individuals: A randomized crossover trial.Resuscitation · 2021Trial
- Repurposing Dexmedetomidine: Early Pharmacological Hypothermia Enhances Neuroprotection and Improves Locomotor and Bladder Functional Recovery after Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Two cases of acute pancreatitis occurring during therapeutic hypothermia for severe brain injury: case report and literature review.Frontiers in medicine · 2026Article
- Sedative Agents, Synthetic Torpor, and Long-Haul Space Travel-A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Sustained metabolic reduction and hypothermia in humans.PloS one · 2025Article
- Alpha-2-adrenergic agonists reduce resting energy expenditure in humans during external cooling.Temperature (Austin, Tex.) · 2024Article
- Global Research and Scientific Publications on Dexmedetomidine Use in Adults for Anesthesia Care between 2001 and 2021: A Bibliometric Analysis.Current therapeutic research, clinical and experimental · 2022Article
- Management of comfort and sedation in neonates with neonatal encephalopathy treated with therapeutic hypothermia.Seminars in fetal & neonatal medicine · 2021Review
- Practical approaches to sedation and analgesia in the newborn.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- State-of-the-art considerations in post-arrest care.Journal of the American College of Emergency Physicians open · 2020Review
- Shallow metabolic depression and human spaceflight: a feasible first step.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Hypothermic properties of dexmedetomidine provide neuroprotection in rats following cerebral ischemia-reperfusion injury.Experimental and therapeutic medicine · 2019Article
- Cooling to Facilitate Metabolic Suppression in Healthy Individuals.Aerospace medicine and human performance · 2019Article
- Optimization of Thermolytic Response to AThe Journal of pharmacology and experimental therapeutics · 2017Article
- Emergency Neurological Life Support: Resuscitation Following Cardiac Arrest.Neurocritical care · 2017Article
- Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response Following Cardiac Arrest: A Comprehensive Review of Preclinical and Clinical Investigations.Therapeutic hypothermia and temperature management · 2016Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeReducing body temperature can prolong tolerance to ischemic injury such as stroke or myocardial infarction, but is difficult and uncomfortable in awake patients because of shivering. We tested the efficacy and safety of the alpha-2-adrenergic agonist dexmedetomidine for suppressing shivering induced by a rapid infusion of cold intravenous fluids.
methodsTen subjects received a rapid intravenous infusion of two liters of cold (4°C) isotonic saline on two separate test days, and we measured their core body temperature, shivering, hemodynamics and sedation for two hours. On one test day, fluid infusion was preceded by placebo infusion. On the other test day, fluid infusion was preceded by 1.0 μg/kg bolus of dexmedetomidine over 10 minutes.
resultsAll ten subjects experienced shivering on placebo days, with shivering beginning at a mean (SD) temperature of 36.6 (0.3)°C. The mean lowest temperature after placebo was 36.0 (0.3)°C (range 35.7-36.5°C). Only 3/10 subjects shivered on dexmedetomidine days, and the mean lowest temperature was 35.7 (0.4)°C (range 35.0-36.3°C). Temperature remained below 36°C for the full two hours in 6/10 subjects. After dexmedetomidine, subjects had moderate sedation and a mean 26 (13) mmHg reduction in blood pressure that resolved within 90 minutes. Heart rate declined a mean 23 (11) bpm after both placebo and dexmedetomidine. Dexmedetomidine produced no respiratory depression.
conclusionDexmedetomidine decreases shivering in normal volunteers. This effect is associated with decreased systolic blood pressure and sedation, but no respiratory depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.