ArticleJournal of the American Chemical Society2015
Supramolecular Glycosylation Accelerates Proteolytic Degradation of Peptide Nanofibrils.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Heterochiral and Heterotypic Self-Assembly of Intrinsically Disordered Peptides Confers Peptide Supercoils with Exceptional Proteolytic Stability.Journal of the American Chemical Society · 2025Article
- Self-assembly of aramid amphiphiles into ultra-stable nanoribbons and aligned nanoribbon threads.Nature nanotechnology · 2021Article
- Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles.Chemical science · 2019Article
- Nucleopeptide Assemblies Selectively Sequester ATP in Cancer Cells to Increase the Efficacy of Doxorubicin.Angewandte Chemie (International ed. in English) · 2018Article
- DNA- and RNA-binding ability of oligoDapT, a nucleobase-decorated peptide, for biomedical applications.International journal of nanomedicine · 2018Article
- Self-assembly of nucleopeptides to interact with DNAs.Interface focus · 2017Article
- Supramolecular catalysis and dynamic assemblies for medicine.Chemical Society reviews · 2017Review
- Supramolecular biofunctional materials.Biomaterials · 2017Review
- Bioinspired assembly of small molecules in cell milieu.Chemical Society reviews · 2017Review
- Design and Synthesis of Nanofibers of Self-assembledTetrahedron · 2016Article
- Heterotypic Supramolecular Hydrogels.Journal of materials chemistry. B · 2016Article
- Rationally introduce multi-competitive binding interactions in supramolecular gels: a simple and efficient approach to develop multi-analyte sensor array.Chemical science · 2016Article
- The Enzyme-instructed assembly of the core of yeast prion Sup35 to form supramolecular hydrogels.Journal of materials chemistry. B · 2016Article
- Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.Chemical reviews · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Despite the recent consensus that the oligomers of amyloid peptides or aberrant proteins are cytotoxic species, there is still a need for an effective way to eliminate the oligomers. Based on the fact that normal proteins are more glycosylated than pathogenic proteins, we show that a conjugate of nucleobase, peptide, and saccharide binds to peptides from molecular nanofibrils and accelerates the proteolytic degradation of the molecular nanofibrils. As the first example of the use of supramolecular glycosylation to dissociate molecular nanofibrils and to accelerate the degradation of peptide aggregates, this work illustrates a new method that ultimately may lead to an effective approach for degrading cytotoxic oligomers of peptides or aberrant proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.