ArticleJournal of clinical medicine2013
Analysis of Various Subsets of Circulating Mononuclear Cells in Asymptomatic Coronary Artery Disease.
Article in Journal of clinical medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed, 25 citations in OpenAlex.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe objective of this study was to evaluate the correlation between multiple cardiovascular risk factors (MCRFs) and circulating mononuclear cells (CMCs) in asymptomatic coronary artery disease patients. DESIGN AND
methods126 subjects (54 male), aged 48 to 62 years, with asymptomatic coronary artery disease (CAD) documented previously with angiography, and 25 healthy volunteers were enrolled in the study. The flow cytometric technique was used for predictably distinguishing cell subsets that depend on the expression of CD14, CD34, Tie-2, CD45, and CD309 (VEGFR2).
resultsThe analysis of the outcome obtained shows a trend of an increase in circulating CD45(-)CD34(+) CMCs and a reduction in CMC population defined as CD14(+)CD309(+) and CD14(+)CD309(+)Tie(2+) in known asymptomatic CAD patients in comparison with healthy volunteers. Substantial correlations between CD45(-)CD34(+) and conventional cardiovascular risk factors (hs-CRP, T2DM, serum uric acid and hypertension) were found in the patient cohort. The concentrations of CD14(+)CD309(+) and CD14(+)CD309(+)Tie(2+) CMCs had effect on such factors as T2DM (RR = 1.21; 95% CI = 1.10-1.40; p = 0.008), hs-CRP > 2.54 mg/L (RR = 1.29; 95% CI = 1.12-1.58; p = 0.006), Agatston score index (RR = 1.20; 95% CI = 1.15-1.27; p = 0.034), and occurrence of three and more cardiovascular risk factors (RR = 1.31; 95% CI = 1.12-1.49; p = 0.008).
conclusionIt is postulated that the reduction in circulating CD14(+)CD309(+) and CD14(+)CD309(+)Tei(2+) CMCs is related to a number of cardiovascular risk factors in asymptomatic patients with known CAD.
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