Evidence map›Paper›PMID 26236952›Full record

ArticleInflammatory bowel diseases2015

High School Diet and Risk of Crohn's Disease and Ulcerative Colitis.

Ashwin N Ananthakrishnan, Hamed Khalili, Mingyang Song, Leslie M Higuchi, James M Richter, Katharina Nimptsch, Kana Wu, Andrew T Chan

Open access · bronzeAbstract read
In one paragraph

Article in Inflammatory bowel diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 7 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 7 syntheses or guidelines pooled it, 116 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Review
  11. Observational
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Early Life and Childhood Environmental Exposures, More Than Genetic Predisposition, Influence Age of Diagnosis in a Diverse Cohort of 2952 Patients With IBD.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024
    Article
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ashwin N Ananthakrishnan*Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; †Departments of Nutrition and Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; ‡Division of Gastroenterology and Nutrition, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts; §Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany; and ‖Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Hamed Khalili
Mingyang Song
Leslie M Higuchi
James M Richter
Katharina Nimptsch
Kana Wu
Andrew T Chan
Boston Children's Hospital · USHarvard University · USBrigham and Women's Hospital · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER · 2000 to 2019
$77.8M
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Oral Contraceptives in the Etiopathogenesis of Crohn's DiseaseK23DK099681 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KHALILI, HAMED · 2013 to 2017
$946k
Mentored Patient-Oriented Research in Digestive DiseasesK24DK098311 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T · 2013 to 2017
$930k
Genetic predictors of anti-TNF treatment response and infections in IBDK23DK097142 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ANANTHAKRISHNAN, ASHWIN N · 2012 to 2016
$846k
Environmental factors and inflammatory bowel diseaseK08DK064256 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI HIGUCHI, LESLIE M · 2003 to 2007
$630k
NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA87969NCI NIH HHS UM1 CA176276NIDDK NIH HHS K08 DK064256NIDDK NIH HHS K23 DK091742NIDDK NIH HHS K23 DK097142NIDDK NIH HHS K23 DK099681NIDDK NIH HHS K24 DK098311NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

backgroundDiet may play an important role in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC); yet, there are few prospective studies of dietary factors. None have examined the association between adolescent diet and risk of inflammatory bowel diseases (CD and UC).

methodsThis study included women enrolled in Nurses' Health Study II who completed a validated high school dietary questionnaire in 1998. We examined the effect of dietary patterns (prudent or Western diet) and individual components of each patterns. We documented incident cases of CD and UC through 2011 based on physician review of medical records and used Cox proportional hazards models adjusting for confounders to estimate hazard ratios and confidence intervals for CD and UC.

resultsOver 763,229 person-years of follow-up, we identified 70 incident cases of CD and 103 cases of UC. Compared with women in the lowest quartile of a prudent diet score (characterized by greater intake of fruits, vegetables, and fish), women in the highest quartile had a 53% lower risk of CD (hazard ratio, 0.47; 95% confidence interval, 0.23-0.98; P trend = 0.04). Specifically, greater intake of fish (P trend = 0.01) and fiber (P trend = 0.06) were associated with lower risk of CD. In contrast, Western diet score was not associated with risk of CD. Neither dietary patterns nor individual food or nutrient groups was associated with UC.

conclusionsAdolescent diet is associated with risk of CD, but not UC, offering insights into disease pathogenesis.

Indexed as

AdolescentAdultColitis, UlcerativeCrohn DiseaseDietDietary FiberDiet SurveysFemaleFruitHumansIncidenceProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSchoolsDietary Fiber

Identifiers

PMID26236952
PMCPMC4567521
OpenAlexW1864656638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.