ArticleJournal of the Royal Society, Interface2015
A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens.
Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases.Bioengineering (Basel, Switzerland) · 2025Review
- 3D visualization of cellular and molecular distributions in human crystalline lenses at different ages.American journal of translational research · 2024Article
- Single-cell RNA sequencing reveals new subtypes of lens superficial tissue in humans.Cell proliferation · 2023Article
- Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens.The Journal of biological chemistry · 2022Review
- Autophagy facilitates age-related cell apoptosis-a new insight from senile cataract.Cell death & disease · 2022Article
- Methodologies to unlock the molecular expression and cellular structure of ocular lens epithelial cells.Frontiers in cell and developmental biology · 2022Article
- Mapping Glucose Uptake, Transport and Metabolism in the Bovine Lens Cortex.Frontiers in physiology · 2022Article
- Lens Stretching Modulates Lens Epithelial Cell Proliferation via YAP Regulation.Investigative ophthalmology & visual science · 2019Article
- Inverse dose-rate effect of ionising radiation on residual 53BP1 foci in the eye lens.Scientific reports · 2019Article
- A biologically based mathematical model for spontaneous and ionizing radiation cataractogenesis.PloS one · 2019Article
- The lens growth process.Progress in retinal and eye research · 2017Review
- The lens actin filament cytoskeleton: Diverse structures for complex functions.Experimental eye research · 2017Review
- The cause and consequence of fiber cell compaction in the vertebrate lens.Experimental eye research · 2017Review
- A full lifespan model of vertebrate lens growth.Royal Society open science · 2017Article
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6 authors.
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Abstract
We present a mathematical (ordered pull-through; OPT) model of the cell-density profile for the mammalian lens epithelium together with new experimental data. The model is based upon dimensionless parameters, an important criterion for inter-species comparisons where lens sizes can vary greatly (e.g. bovine (approx. 18 mm); mouse (approx. 2 mm)) and confirms that mammalian lenses scale with size. The validated model includes two parameters: β/α, which is the ratio of the proliferation rate in the peripheral and in the central region of the lens; and γ(GZ), a dimensionless pull-through parameter that accounts for the cell transition and exit from the epithelium into the lens body. Best-fit values were determined for mouse, rat, rabbit, bovine and human lens epithelia. The OPT model accounts for the peak in cell density at the periphery of the lens epithelium, a region where cell proliferation is concentrated and reaches a maximum coincident with the germinative zone. The β/α ratio correlates with the measured FGF-2 gradient, a morphogen critical to lens cell survival, proliferation and differentiation. As proliferation declines with age, the OPT model predicted age-dependent changes in cell-density profiles, which we observed in mouse and human lenses.
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