ArticleNeurologia medico-chirurgica2015
Pathophysiology, Diagnosis, and Treatment of Radiation Necrosis in the Brain.
Article in Neurologia medico-chirurgica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Symptomatic radiation necrosis following intracranial brachytherapy: a systematic review and meta-analysis.Journal of neuro-oncology · 2026Pooled it
- Differentiating radiation necrosis from tumor recurrence: a systematic review and diagnostic meta-analysis comparing imaging modalities.Journal of neuro-oncology · 2023Pooled it
- Comparative dosing of bevacizumab for radiation necrosis: impact of tumor type on edema response.Journal of neuro-oncology · 2026Article
- Comparative study of radiomics features between ASL and DSC perfusion-weighted imaging in distinguishing radiation-induced brain injury from glioma recurrence.Neuroradiology · 2026Article
- Cesium-131 brachytherapy for central nervous system salvage therapy.Journal of neuro-oncology · 2026Article
- Histopathologically confirmed radiation necrosis: Risk factors and clinical outcomes in patients with primary brain tumors.Neuro-oncology practice · 2025Article
- Recent advances in laser interstitial thermal therapy in the treatment of brain metastases and radiation necrosis.Lasers in medical science · 2025Review
- Reirradiation using helical tomotherapy-based hypofractionated stereotactic radiotherapy for 19 brain metastases after the second recurrence of distant brain failure: a case report and literature review.Translational lung cancer research · 2025Article
- Evaluating the efficacy and safety of Anlotinib in conjunction with stereotactic radiosurgery for small cell lung cancer patients with brain metastases.Oncology research · 2025Article
- Radionecrosis mimicking pseudo‑progression in a patient with lung cancer and brain metastasis following the combination of anti‑PD‑1 therapy and stereotactic radiosurgery: A case report.Oncology letters · 2023Article
- Low-Dose Bevacizumab for the Treatment of Focal Radiation Necrosis of the Brain (fRNB): A Single-Center Case Series.Cancers · 2023Article
- Neoadjuvant fractionated stereotactic radiotherapy followed by piecemeal resection of brain metastasis: a case series of 20 patients.International journal of clinical oncology · 2022Article
- Review
- [EJNMMI research · 2020Article
- High uptake ofEJNMMI research · 2020Article
- Salvage craniotomy for treatment-refractory symptomatic cerebral radiation necrosis.Neuro-oncology practice · 2020Article
- Adrenal Insufficiency in Patients with Corticosteroid-Refractory Cerebral Radiation Necrosis Treated with Bevacizumab.Journal of clinical medicine · 2019Article
- Brain MR findings in patients treated with particle therapy for skull base tumors.Insights into imaging · 2019Review
- Incidence of radionecrosis in single-fraction radiosurgery compared with fractionated radiotherapy in the treatment of brain metastasis.Current oncology (Toronto, Ont.) · 2019Article
- Bevacizumab treatment for radiation brain necrosis: mechanism, efficacy and issues.Molecular cancer · 2019Review
Corrections and comments
- Reprint of
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New radiation modalities have made it possible to prolong the survival of individuals with malignant brain tumors, but symptomatic radiation necrosis becomes a serious problem that can negatively affect a patient’s quality of life through severe and lifelong effects. Here we review the relevant literature and introduce our original concept of the pathophysiology of brain radiation necrosis following the treatment of brain, head, and neck tumors. Regarding the pathophysiology of radiation necrosis, we introduce two major hypotheses: glial cell damage or vascular damage. For the differential diagnosis of radiation necrosis and tumor recurrence, we focus on the role of positron emission tomography. Finally, in accord with our hypothesis regarding the pathophysiology, we describe the promising effects of the anti-vascular endothelial growth factor antibody bevacizumab on symptomatic radiation necrosis in the brain.
Identifiers
26236802What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.