Evidence map›Paper›PMID 26236743›Full record

ArticleBioMed research international2015

Immunohistochemical Expression of Collagens in the Skin of Horses Treated with Leukocyte-Poor Platelet-Rich Plasma.

Maria Verônica de Souza, Mariana Brettas Silva, José de Oliveira Pinto, Marianna Barros de Souza Lima, Júlio Crepaldi, Gabriela Francine Martins Lopes, Hélio Batista dos Santos, Rosy Iara Maciel de Azambuja Ribeiro, Ralph Gruppi Thomé

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In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria Verônica de SouzaDepartamento de Veterinária, Universidade Federal de Viçosa, Campus Universitário, Avenida P.H. Rolfs, s/n, 36570-900 Viçosa, MG, Brazil.
Mariana Brettas SilvaDepartamento de Veterinária, Universidade Federal de Viçosa, Campus Universitário, Avenida P.H. Rolfs, s/n, 36570-900 Viçosa, MG, Brazil.
José de Oliveira PintoDepartamento de Veterinária, Universidade Federal de Viçosa, Campus Universitário, Avenida P.H. Rolfs, s/n, 36570-900 Viçosa, MG, Brazil.
Marianna Barros de Souza LimaClínica Médica Planeta Animal, Rua Araguaia 30, Bairro São Mateus, 36025-240 Juiz de Fora, MG, Brazil.
Júlio CrepaldiDepartamento de Veterinária, Universidade Federal de Viçosa, Campus Universitário, Avenida P.H. Rolfs, s/n, 36570-900 Viçosa, MG, Brazil.
Gabriela Francine Martins LopesLaboratório de Patologia Experimental, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Rua Sebastião Gonçalves Coelho 400, Bairro Chanadour, 35501-296 Divinópolis, MG, Brazil.
Hélio Batista dos SantosLaboratório de Processamento de Tecido, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Rua Sebastião Gonçalves Coelho 400, Bairro Chanadour, 35501-296 Divinópolis, MG, Brazil.
Rosy Iara Maciel de Azambuja RibeiroLaboratório de Patologia Experimental, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Rua Sebastião Gonçalves Coelho 400, Bairro Chanadour, 35501-296 Divinópolis, MG, Brazil.
Ralph Gruppi ThoméLaboratório de Processamento de Tecido, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Rua Sebastião Gonçalves Coelho 400, Bairro Chanadour, 35501-296 Divinópolis, MG, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the immunohistochemical expression of type I (COL I) and III (COL III) collagens during the healing process of skin treated with leukocyte-poor platelet-rich plasma (LP-PRP). Seven healthy gelding crossbred horses aged 16 to 17 years were used. Two rectangle-shaped wounds were created surgically in the right and left gluteal regions. Twelve hours after wound induction, 0.5 mL of the LP-PRP was administered in each edge of the wounds of one of the gluteal regions. The contralateral region was used as control (CG). Three samples were obtained: after wound induction (T0), 14 days (T1) of healing process, and after complete closure of the skin (T2). The normal skin (T0) showed strong staining for type III and I collagen in papillary and reticular dermis, respectively. In the scar of the treated group, COL III showed important (p < 0.05) increase in immunoreaction in T2 compared with T1. The administration of a single dose of LP-PRP 12 h after induction of wound in horses does not influence formation of collagens I and III. However, the intense labeling for COL III suggests that the tissue was still weak during the macroscopic closure of the wound, demonstrating that healing was not completely finished.

Indexed as

Platelet-Rich PlasmaSkinWounds and InjuriesAnimalsCollagenGene Expression RegulationHorsesImmunohistochemistryWound HealingCollagen

Identifiers

PMID26236743
PMCPMC4508476

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.