Evidence map›Paper›PMID 26236629›Full record

ArticleNeuroImage. Clinical2015

White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration.

Laura E Downey, Colin J Mahoney, Aisling H Buckley, Hannah L Golden, Susie M Henley, Nicole Schmitz, Jonathan M Schott, Ivor J Simpson, Sebastien Ourselin, Nick C Fox and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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  20. Laughter as a paradigm of socio-emotional signal processing in dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Laura E DowneyDementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
Colin J MahoneyDementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
Aisling H BuckleyDementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
Hannah L GoldenDementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
Susie M HenleyDementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
Nicole SchmitzDementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
Jonathan M SchottDementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
Ivor J SimpsonDementia Research Centre, UCL Institute of Neurology, University College London, London, UK ; Centre for Medical Image Computing, University College London, London, UK.
Sebastien OurselinDementia Research Centre, UCL Institute of Neurology, University College London, London, UK ; Centre for Medical Image Computing, University College London, London, UK.
Nick C FoxDementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
Sebastian J CrutchDementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
Jason D WarrenDementia Research Centre, UCL Institute of Neurology, University College London, London, UK.
UK Dementia Research Institute · GBUniversity College London · GB

Funding

Medical Research Council G0801306Wellcome Trust 091673
6 · The paper itself

Abstract

Impairments of social cognition are often leading features in frontotemporal lobar degeneration (FTLD) and likely to reflect large-scale brain network disintegration. However, the neuroanatomical basis of impaired social cognition in FTLD and the role of white matter connections have not been defined. Here we assessed social cognition in a cohort of patients representing two core syndromes of FTLD, behavioural variant frontotemporal dementia (bvFTD; n = 29) and semantic variant primary progressive aphasia (svPPA; n = 15), relative to healthy older individuals (n = 37) using two components of the Awareness of Social Inference Test, canonical emotion identification and sarcasm identification. Diffusion tensor imaging (DTI) was used to derive white matter tract correlates of social cognition performance and compared with the distribution of grey matter atrophy on voxel-based morphometry. The bvFTD and svPPA groups showed comparably severe deficits for identification of canonical emotions and sarcasm, and these deficits were correlated with distributed and overlapping white matter tract alterations particularly affecting frontotemporal connections in the right cerebral hemisphere. The most robust DTI associations were identified in white matter tracts linking cognitive and evaluative processing with emotional responses: anterior thalamic radiation, fornix (emotion identification) and uncinate fasciculus (sarcasm identification). DTI associations of impaired social cognition were more consistent than corresponding grey matter associations. These findings delineate a brain network substrate for the social impairment that characterises FTLD syndromes. The findings further suggest that DTI can generate sensitive and functionally relevant indexes of white matter damage in FTLD, with potential to transcend conventional syndrome boundaries.

Indexed as

Social PerceptionAgedAtrophyDiffusion Tensor ImagingFemaleFrontotemporal DementiaGray MatterHumansMaleMiddle AgedPrimary Progressive Nonfluent AphasiaWhite MatterDiffusion tensor imagingEmotionFrontotemporal dementiaSarcasmSocial cognitionVoxel based morphometry

Identifiers

PMID26236629
PMCPMC4513187
OpenAlexW835185512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.