Evidence map›Paper›PMID 26236565›Full record

ArticleOpen journal of immunology2015

B Cells with Regulatory Function in Animal Models of Autoimmune and Non-Autoimmune Diseases.

Mei Lin, Zuomin Wang, Xiaozhe Han

Abstract read
In one paragraph

Article in Open journal of immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mei LinDepartment of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, USA ; Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Zuomin WangDepartment of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Xiaozhe HanDepartment of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, USA.

Funding

Regulatory B Cells in the Amelioration of Immune-Mediated Periodontal DiseaseR01DE025255 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI HAN, XIAOZHE · 2015 to 2025
$5.8M
Regulation of B-Cell Apoptosis by TLR Signaling in Periodontal DiseaseR21DE021837 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI HAN, XIAOZHE · 2011 to 2012
$543k
Regulatory B cells in the amelioration of immune-mediated periodontal diseaseR56DE023807 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI HAN, XIAOZHE · 2014 to 2014
$476k
NIDCR NIH HHS L30 DE020037NIDCR NIH HHS R01 DE025255NIDCR NIH HHS R21 DE021837NIDCR NIH HHS R56 DE023807
6 · The paper itself

Abstract

Although the identification of B cell subsets with negative regulatory functions and the definition of their mechanisms of action are recent events, the important negative regulatory roles of B cells in immune responses are now broadly recognized. There is an emerging appreciation for the pivotal role played by B cells in several areas of human diseases including autoimmune diseases and non-autoimmune diseases such as parasite infections and cancer. The recent research advancement of regulatory B cells in human disease coincides with the vastly accelerated pace of research on the bridging of innate and adaptive immune system. Current study and our continued research may provide better understanding of the mechanisms that promote regulatory B10 cell function to counteract exaggerated immune activation in autoimmune as well as non-autoimmune conditions. This review is focused on the current knowledge of BREG functions studied in animal models of autoimmune and non-autoimmune diseases.

Indexed as

Animal ModelsAutoimmune DiseaseBregsIL-10Immune Regulation

Identifiers

PMID26236565
PMCPMC4517676

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.