Evidence map›Paper›PMID 26236558›Full record

ArticleJournal of AIDS & clinical research2015

Intrahepatic Cholestasis of Pregnancy and Serum Bile Acids in HIV-Infected Pregnant Women.

Adriana Weinberg, Amanda Allshouse, Kay Kinzie, Alice Cho, Jill K Davies, Elizabeth J Mc Farland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of AIDS & clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Adriana WeinbergDepartment of Pediatrics, the University of Colorado School of Medicine, USA ; Department of Medicine, the University of Colorado School of Medicine, USA ; Department of Pathology, the University of Colorado School of Medicine, USA ; University of Colorado Hospital, USA ; Childrens Hospital Colorado, Aurora CO, USA.
Amanda AllshouseDepartment of Preventative Medicine, the University of Colorado School of Medicine, USA ; Childrens Hospital Colorado, Aurora CO, USA.
Kay KinzieDepartment of Pediatrics, the University of Colorado School of Medicine, USA ; Childrens Hospital Colorado, Aurora CO, USA.
Alice ChoDepartment of Pediatrics, the University of Colorado School of Medicine, USA.
Jill K DaviesDepartments of Obstetrics and Gynecology, the University of Colorado School of Medicine, USA ; University of Colorado Hospital, USA ; Denver Health Medical Center, Denver CO, USA.
Elizabeth J Mc FarlandDepartment of Pediatrics, the University of Colorado School of Medicine, USA ; Childrens Hospital Colorado, Aurora CO, USA.
University of Colorado Hospital · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
ZORVIRAX ORAL SUSPENSION FOR SEVERE CHILDHOOD HERPES VIRUS INFECTIONSM01RR000069 · NCRR · UNIVERSITY OF COLORADO DENVER · PI KRUGMAN, RICHARD D. · 1985 to 2008
$22.1M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
NCATS NIH HHS UL1 TR000154NCATS NIH HHS UL1 TR001082NCRR NIH HHS M01 RR000069
6 · The paper itself

Abstract

objectivesIntra-hepatic cholestasis of pregnancy (ICP) is uncommon, but has severe effects on pregnancy outcomes. ICP is characterized by elevated serum bile acids and liver enzymes and preferentially affects women with liver disorders. We compared bile acids and pregnancy outcomes of HIV-infected pregnant women, who commonly have elevated live enzymes, with uninfected controls.

methodsTwenty-four HIV-infected, including 2 co-infected with hepatitis C virus (HCV), and 25 uninfected women were tested during early and late pregnancy and postpartum.

resultsAfter exclusion of the HCV-infected women, serum bile acids were similar in HIV-infected and uninfected participants. -glutamyl transpeptidase was elevated in HIV-infected compared with uninfected women during pregnancy and postpartum. Bilirubin and aspartate transaminase were higher in uninfected compared with HIV-infected women in early pregnancy, but subsequently similar. Bile acids in late pregnancy correlated with bile acids in the baby at birth. An HIV- and HCV-co-infected pregnant woman with active hepatitis developed ICP complicated by fetal distress. Another co-infected participant without active hepatitis had an uneventful pregnancy and delivery.

conclusionIn the absence of HCV co-infection, bile acid metabolism appeared to be similar in HIV-infected and uninfected pregnant women. Both HIV-infected and uninfected pregnant women had mild liver enzyme elevations.

Indexed as

Antiretroviral TherapyBile acidsHepatitis C virusHuman Immunodeficiency VirusIntrahepatic cholestasisLiver functionPregnancy

Identifiers

PMID26236558
PMCPMC4519986
OpenAlexW2247787286

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.