Evidence map›Paper›PMID 26236460›Full record

ArticleMedChemComm

Structure-Based Design, Synthesis by Click Chemistry and

Dilip K Tosh, Silvia Paoletta, Zhoumou Chen, Steven Crane, John Lloyd, Zhan-Guo Gao, Elizabeth T Gizewski, John A Auchampach, Daniela Salvemini, Kenneth A Jacobson

Open access · greenAbstract read
In one paragraph

Article in MedChemComm. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Potent and Selective Human 5-HTJournal of medicinal chemistry · 2024
    Article
  2. 2-Substituted (N)-Methanocarba AACS pharmacology & translational science · 2024
    Article
  3. Characterization of Dual-Acting AACS pharmacology & translational science · 2022
    Article
  4. Interaction of AEuropean journal of medicinal chemistry · 2022
    Article
  5. Evidence for the Interaction of AMolecular pharmacology · 2019
    Article
  6. AMedicinal research reviews · 2018
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Dilip K ToshLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 USA.
Silvia PaolettaLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 USA.
Zhoumou ChenDepartment of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri 63104 USA.
Steven CraneLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 USA.
John LloydLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 USA.
Zhan-Guo GaoLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 USA.
Elizabeth T GizewskiDepartment of Pharmacology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226 USA.
John A AuchampachDepartment of Pharmacology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226 USA.
Daniela SalveminiDepartment of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri 63104 USA.
Kenneth A JacobsonLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 USA.
Institute of Bioorganic Chemistry · BYMedical College of Wisconsin · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institutes of Health · USPhysiological Society · GBSaint Louis University · US

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Computer Modeling of G Protein-Coupled ReceptorsZIADK031126 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$6.6M
Role of Adenosine Receptors in Tissue ProtectionR01HL077707 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2005 to 2014
$3.4M
Intramural NIH HHS ZIA DK031117NHLBI NIH HHS R01 HL077707
6 · The paper itself

Abstract

2-Arylethynyl derivatives of (N)-methanocarba adenosine 5'-uronamides are selective A

Indexed as

click chemistryG protein-coupled receptormolecular modelingneuropathic painnucleoside

Identifiers

PMID26236460
PMCPMC4517612
OpenAlexW2073824204

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.