ArticleOxidative medicine and cellular longevity2015
Neuroprotection by Cocktails of Dietary Antioxidants under Conditions of Nerve Growth Factor Deprivation.
Article in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Review
- Advances in Antioxidant Applications for CombatingToxics · 2023Review
- Pronator teres nerve branch transfer to the extensor carpi radialis brevis nerve branch for wrist extension reconstruction in proximal radial nerve injury following humeral shaft fractures.BMC musculoskeletal disorders · 2022Article
- Unveiling a Hidden Biomarker of Inflammation and Tumor Progression: The 65 kDa Isoform of MMP-9 New Horizons for Therapy.Current issues in molecular biology · 2021Article
- Review
- ROS networks: designs, aging, Parkinson's disease and precision therapies.NPJ systems biology and applications · 2020Article
- Differential Modulation of NF-Oxidative medicine and cellular longevity · 2019Article
- Diet, Gut Microbiota, and Vitamins D + A in Multiple Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- α- and β-Naphthoflavone synergistically attenuate HExperimental and therapeutic medicine · 2017Article
- Are Polyphenols Strong Dietary Agents Against Neurotoxicity and Neurodegeneration?Neurotoxicity research · 2016Review
- Modulation of neurotrophic signaling pathways by polyphenols.Drug design, development and therapy · 2016Review
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Authors and funding
11 authors.
Funding
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Abstract
Dietary antioxidants may be useful in counteracting the chronic inflammatory status in neurodegenerative diseases by reducing oxidative stress due to accumulation of reactive oxygen species (ROS). In this study, we newly described the efficacy of a number of dietary antioxidants (polyphenols, carotenoids, thiolic compounds, and oligoelements) on viability of neuronal PC12 cells following Nerve Growth Factor (NGF) deprivation, a model of age-related decrease of neurotrophic support that triggers neuronal loss. Neuroprotection by antioxidants during NGF deprivation for 24 h was largely dependent on their concentrations: all dietary antioxidants were able to efficiently support cell viability by reducing ROS levels and restoring mitochondrial function, while preserving the neuronal morphology. Moreover, ROS reduction and neuroprotection during NGF withdrawal were also achieved with defined cocktails of 3-6 different antioxidants at concentrations 5-60 times lower than those used in single treatments, suggesting that their antioxidant activity was preserved also at very low concentrations. Overall, these data indicate the beneficial effects of antioxidants against oxidative stress induced by decreased NGF availability and suggest that defined cocktails of dietary factors at low concentrations might be a suitable strategy to reduce oxidative damage in neurodegenerative diseases, while limiting possible side effects.
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