ArticleFrontiers in microbiology2015
NagC represses N-acetyl-glucosamine utilization genes in Vibrio fischeri within the light organ of Euprymna scolopes.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- ROK family regulator NagC promotes prodigiosin biosynthesis independent ofApplied and environmental microbiology · 2024Article
- A lasting symbiosis: how Vibrio fischeri finds a squid partner and persists within its natural host.Nature reviews. Microbiology · 2021Review
- The Bacterial Enhancer Binding Protein VasH Promotes Expression of a Type VI Secretion System in Vibrio fischeri during Symbiosis.Journal of bacteriology · 2020Article
- Sulfur availability for Vibrio fischeri growth during symbiosis establishment depends on biogeography within the squid light organ.Molecular microbiology · 2019Article
- Catabolism of mucus components influences motility of Vibrio cholerae in the presence of environmental reservoirs.PloS one · 2018Article
- An Expanded Transposon Mutant Library Reveals that Vibrio fischeri δ-Aminolevulinate Auxotrophs Can Colonize Euprymna scolopes.Applied and environmental microbiology · 2017Article
- The NAG Sensor NagC Regulates LEE Gene Expression and Contributes to Gut Colonization byFrontiers in cellular and infection microbiology · 2017Article
- Niche-Specific Impact of a Symbiotic Function on the Persistence of Microbial Symbionts within a Natural Host.Applied and environmental microbiology · 2016Article
- Intraspecific Competition Impacts Vibrio fischeri Strain Diversity during Initial Colonization of the Squid Light Organ.Applied and environmental microbiology · 2016Article
- Insights into flagellar function and mechanism from the squid-vibrio symbiosis.NPJ biofilms and microbiomesReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Bacteria often use transcription factors to regulate the expression of metabolic genes in accordance to available nutrients. NagC is a repressor conserved among γ-proteobacteria that regulates expression of enzymes involved in the metabolism of N-acetyl-glucosamine (GlcNAc). The polymeric form of GlcNAc, known as chitin, has been shown to play roles in chemotactic signaling and nutrition within the light organ symbiosis established between the marine bacterium Vibrio fischeri and the Hawaiian squid Euprymna scolopes. Here, we investigate the impact of NagC regulation on the physiology of V. fischeri. We find that NagC repression contributes to the fitness of V. fischeri in the absence of GlcNAc. In addition, the inability to de-repress expression of NagC-regulated genes reduces the fitness of V. fischeri in the presence of GlcNAc. We find that chemotaxis toward GlcNAc or chitobiose, a dimeric form of GlcNAc, is independent of NagC regulation. Finally, we show that NagC represses gene expression during the early stages of symbiosis. Our data suggest that the ability to regulate gene expression with NagC contributes to the overall fitness of V. fischeri in environments that vary in levels of GlcNAc. Furthermore, our finding that NagC represses gene expression within the squid light organ during an early stage of symbiosis supports the notion that the ability of the squid to provide a source of GlcNAc emerges later in host development.
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