Evidence map›Paper›PMID 26236302›Full record

ArticleFrontiers in microbiology2015

In vitro interaction of Stenotrophomonas maltophilia with human monocyte-derived dendritic cells.

Emanuela Roscetto, Laura Vitiello, Rosa Muoio, Amata A Soriano, Vita D Iula, Antonio Vollaro, Eliana De Gregorio, Maria R Catania

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Gut microbes · 2026
    Article
  2. Frontiers in microbiology · 2026
    Article
  3. A guide toFrontiers in cellular and infection microbiology · 2023
    Review
  4. Review
  5. Review
  6. Review
  7. Journal of bacteriology · 2019
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emanuela RoscettoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II , Napoli, Italy.
Laura VitielloLaboratorio di Immunologia Cellulare e Molecolare, Istituto di Ricovero e Cura a Carattere Scientifico , San Raffaele Pisana, Rome, Italy.
Rosa MuoioDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II , Napoli, Italy.
Amata A SorianoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II , Napoli, Italy.
Vita D IulaDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II , Napoli, Italy.
Antonio VollaroDAI Medicina di Laboratorio, Azienda Ospedaliera Universitaria Federico II , Napoli, Italy.
Eliana De GregorioDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II , Napoli, Italy.
Maria R CataniaDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II , Napoli, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stenotrophomonas maltophilia is increasingly identified as an opportunistic pathogen in immunocompromised, cancer and cystic fibrosis (CF) patients. Knowledge on innate immune responses to S. maltophilia and its potential modulation is poor. The present work investigated the ability of 12 clinical S. maltophilia strains (five from CF patients, seven from non-CF patients) and one environmental strain to survive inside human monocyte-derived dendritic cells (DCs). The effects of the bacteria on maturation of and cytokine secretion by DCs were also measured. S. maltophilia strains presented a high degree of heterogeneity in internalization and intracellular replication efficiencies as well as in the ability of S. maltophilia to interfere with normal DCs maturation. By contrast, all S. maltophilia strains were able to activate DCs, as measured by increase in the expression of surface maturation markers and proinflammatory cytokines secretion.

Indexed as

cystic fibrosiscytokines secretionDC maturation markersinnate immune responseopportunistic pathogen

Identifiers

PMID26236302
PMCPMC4504169

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.