ArticleFrontiers in behavioral neuroscience2015
Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- Fear conditioning and extinction in obsessive-compulsive disorder: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Mild concussion impairs extinction of avoidance and alters respective brain circuits in male rats.Experimental neurology · 2026Article
- Diazepam selectively biases approach during threat-reward conflict while sparing reactive avoidance.Psychopharmacology · 2026Article
- Male Sapap3 knockout mice show threat bias under conflict during platform-mediated avoidance task: effects of extinction with response prevention and implications for obsessive compulsive disorder.Translational psychiatry · 2026Article
- Rats use darting as a strategy to navigate between reward and safety during platform-mediated active avoidance under different social contexts.bioRxiv : the preprint server for biology · 2026Article
- A corticostriatal circuit mediates the switching of defensive responses to an approaching threat.Translational psychiatry · 2026Article
- Darting during platform-mediated avoidance in male and female rats is spatially organized between reward and safety locations.Frontiers in behavioral neuroscience · 2026Article
- Developmentally distinct architectures in top-down pathways controlling threat avoidance.Nature neuroscience · 2025Article
- Generalization and extinction of platform-mediated avoidance in male and female rats.Scientific reports · 2025Article
- Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors.Research square · 2025Article
- Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors.bioRxiv : the preprint server for biology · 2025Article
- Persistent Threat Avoidance Following Negative Reinforcement Is Not Associated with Elevated State Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Social context modulates active avoidance: Contributions of the anterior cingulate cortex in male and female rats.Neurobiology of stress · 2025Article
- A Prefrontal→Periaqueductal Gray Pathway Differentially Engages Autonomic, Hormonal, and Behavioral Features of the Stress-Coping Response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Behavioral outputs and overlapping circuits between conditional fear and active avoidance.Neurobiology of learning and memory · 2024Review
- The Role of the Medial Prefrontal Cortex in Spatial Margin of Safety Calculations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Expectation of pain and relief: A dynamical model of the neural basis for pain-trauma co-morbidity.Neuroscience and biobehavioral reviews · 2024Review
- Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states.Neuron · 2024Article
- Active avoidance recruits the anterior cingulate cortex regardless of social context in male and female rats.Research square · 2024Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Persistent avoidance is a prominent symptom of anxiety disorders and is often resistant to extinction-based therapies. Little is known about the circuitry mediating persistent avoidance. Using a recently described platform-mediated active avoidance task, we assessed activity in several structures with c-Fos immuno-labeling. In Task 1, rats were conditioned to avoid a tone-signaled shock by moving to a safe platform, and then were extinguished over two days. One day later, failure to retrieve extinction correlated with increased activity in the prelimbic prefrontal cortex (PL), ventral striatum (VS), and basal amygdala (BA), and decreased activity in infralimbic prefrontal cortex (IL), consistent with pharmacological inactivation studies. In Task 2, the platform was removed during extinction training and fear (suppression of bar pressing) was extinguished to criterion over 3-5 days. The platform was then returned in a post-extinction test. Under these conditions, avoidance levels were equivalent to Experiment 1 and correlated with increased activity in PL and VS, but there was no correlation with activity in IL or BA. Thus, persistent avoidance can occur independently of deficits in fear extinction and its associated structures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.