ArticleJournal of clinical biochemistry and nutrition2015
Biochemical effects, hypolipidemic and anti-inflammatory activities of Artemisia vulgaris extract in hypercholesterolemic rats.
Article in Journal of clinical biochemistry and nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Trial
- From ancient herb to modern miracle: an in-depth analysis of the cardioprotective effects of artemisinin and its derivatives.Journal of geriatric cardiology : JGC · 2026Article
- Article
- Isolation and anti-neuroinflammation activity of sesquiterpenoids from Artemisia argyi: computational simulation and experimental verification.BMC complementary medicine and therapies · 2024Article
- Wild and MicropropagatedPlants (Basel, Switzerland) · 2023Article
- Artemisia Species with High Biological Values as a Potential Source of Medicinal and Cosmetic Raw Materials.Molecules (Basel, Switzerland) · 2022Review
- Cardioprotective properties of Artemisia herba alba nanoparticles against heart attack in rats: A study of the antioxidant and hypolipidemic activities.Saudi journal of biological sciences · 2022Article
- In vivo anti-lipidemic and antioxidant potential of collagen peptides obtained from great hammerhead shark skin waste.Journal of food science and technology · 2022Article
- Phytochemistry and pharmacological activity of the genus artemisia.Archives of pharmacal research · 2021Review
- Anti-Inflammatory Activity ofTheScientificWorldJournal · 2021Article
- Significance ofMolecules (Basel, Switzerland) · 2020Review
- Paraoxonases: metabolic role and pharmacological projection.Naunyn-Schmiedeberg's archives of pharmacology · 2018Review
- Digital Gene Expression Profiling Analysis of Aged Mice under Moxibustion Treatment.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- The role ofAvicenna journal of phytomedicineArticle
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Authors and funding
1 author.
Funding
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Abstract
The purpose of the present study was to investigate hypolipidemic and anti-inflammatory effects of Artemisia vulgaris extract in hypercholesterolemic rats. Hypercholesterolemia was induced by feeding of rats with high fat diet containing 3% cholesterol in olein oil, for 8 weeks. Feeding of rats with high fat diet for 8 weeks, leading to a significant increase in serum triglycerides, total cholesterol, low density lipoprotein cholesterol, malondialdehyde and nitric oxide, tumor necrosis factor-α levels and a significant decrease in serum high density lipoprotein cholesterol level, liver hydroxymethylglutaryl-CoA reductase activity and paraoxonase-1 activities as compared to the normal control group. Treatment of high fat diet rats with Artemisia vulgaris extract for 4 weeks at a dose of 100 mg/kg per day, resulted in normalized serum lipid profile, a significant increase in paraoxonase-1 activity and decrease in serum malondialdehyde, nitric oxide and tumor necrosis factor-α level as compared to high fat diet-treated animals. Also the extract caused a significant decrease in hydroxymethylglutaryl-CoA reductase activity as compared with both high fat diet-treated animals and control ones. In conclusion, Artemisia vulgaris extract has hypolipidemic, anti-inflammatory, antioxidant properties; it may serve as a source for the prevention of atherosclerosis and cardiovascular diseases.
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