ArticleJournal of clinical hypertension (Greenwich, Conn.)2015
Exaggerated Exercise Blood Pressure Response and Future Cardiovascular Disease.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 72 citations in OpenAlex.
- Short-term water deprivation attenuates the exercise pressor reflex in older female adults.Physiological reports · 2020Trial
- Determinants and prognostic value of blood pressure trajectories during graded exercise.European journal of applied physiology · 2026Article
- Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026Review
- Experiments and Simulations to Assess Exercise-Induced Pressure Drop Across Aortic Coarctations.Journal of biomechanical engineering · 2025Article
- Determinants of Longitudinal Changes in Exercise Blood Pressure in a Population of Young Athletes: The Role of BMI.Journal of cardiovascular development and disease · 2025Article
- Hypertensive Response to Exercise as an Early Marker of Disease Development.Biomedicines · 2024Review
- Hypertensive Response to Exercise in Normotensive Men and Women with Abdominal Obesity: Association with Subclinical Adverse Cardiac Remodeling.Journal of clinical medicine · 2024Article
- Accuracy of the WatchBP Office Central as a Type 2 device for non-invasive estimation of central aortic blood pressure in children and adolescents.Journal of human hypertension · 2024Article
- Evaluation of Left Ventricular Systolic Functions of Patients with Exaggerated High Blood Pressure Response to Treadmill Exercise Test with Two-Dimensional Longitudinal Strain Imaging.Anatolian journal of cardiology · 2024Article
- Multiple factors are related to the development of exaggerated blood pressure response to exercise.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- CAVI (Cardio-Ankle Vascular Index) as an independent predictor of hypertensive response to exercise.BMC cardiovascular disorders · 2024Article
- Acute nasal breathing lowers diastolic blood pressure and increases parasympathetic contributions to heart rate variability in young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Exercise blood pressure and heart rate responses to graded exercise testing in intermediate versus morning chronotypes with obesity.American journal of physiology. Heart and circulatory physiology · 2023Observational
- Prognostic Implications of Exercise-Induced Hypertension in Adults With Repaired Coarctation of Aorta.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Six months of unsupervised exercise training lowers blood pressure during moderate, but not vigorous, aerobic exercise in adults with well-healed burn injuries.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Immediate post-exercise blood pressure and arterial stiffness in hypertensive and normotensive older females.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Aerobic exercise training improves endothelial function and attenuates blood pressure reactivity during maximal exercise in chronic kidney disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Effect of regular endurance exercises on management of cardiovascular health in middle-aged men.Journal of exercise rehabilitation · 2022Article
- Relationship Between Cardiorespiratory Fitness, Baseline Blood Pressure and Hypertensive Response to Exercise in the Ferrari Corporate Population.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022Article
- Exaggerated Exercise Blood Pressure as a Marker of Baroreflex Dysfunction in Normotensive Metabolic Syndrome Patients.Frontiers in neuroscience · 2021Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exaggerated blood pressure (BP) response to exercise predicts future hypertension. However, there is considerable lack of understanding regarding the mechanism of how this abnormal response is generated, and how it relates to the future establishment of cardiovascular disease. The authors studied 82 healthy male volunteers without cardiovascular risk factors. The participants were categorized into two age-matched groups depending on their exercise systolic BP (ExSBP) rise after 3 minutes of exercise using a submaximal step test: exaggerated ExSBP group (hyper-responders [peak SBP ≥ 180 mm Hg]) and low ExSBP responder group (hypo-responders [peak SBP <180 mm Hg]). Forearm venous occlusion plethysmography and intra-arterial infusions of acetylcholine (ACh), N(G)-monomethyl-L-arginine (L-NMMA), sodium nitroprusside (SNP), and norepinephrine (NE) were used to assess vascular reactivity. Proximal aortic compliance was assessed with ultrasound, and neurohormonal blood sampling was performed at rest and during peak exercise. The hyper-responder group exhibited a significantly lower increase in forearm blood flow (FBF) with ACh compared with the hypo-responder group (ΔFBF 215% [14] vs 332.3% [28], mean [standard error of the mean]; P<.001), as well as decreased proximal aortic compliance. The vasoconstrictive response to L-NMMA was significantly impaired in the hyper-responder group in comparison to the hypo-responder group (ΔFBF -40.2% [1.6] vs -50.2% [2.6]; P<.05). In contrast, the vascular response to SNP and NE were comparable in both groups. Peak exercise plasma angiotensin II levels were significantly higher in the hyper-responder group (31 [1] vs 23 [2] pg/mL, P=.01). An exaggerated BP response to exercise is related to endothelial dysfunction, decreased proximal aortic compliance, and increased exercise-related neurohormonal activation, the constellation of which may explain future cardiovascular disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.