ReviewJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2015
True Gold or Pyrite: A Review of Reference Point Indentation for Assessing Bone Mechanical Properties In Vivo.
Review in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Added Value of Impact Microindentation in the Evaluation of Bone Fragility: A Systematic Review of the Literature.Frontiers in endocrinology · 2020Pooled it
- Bone Fragility: Time to Address the Matrix.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Fracture risk assessment in diabetes mellitus.Frontiers in endocrinology · 2022Review
- Bone Phenotyping Approaches in Human, Mice and Zebrafish - Expert Overview of the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork").Frontiers in endocrinology · 2021Review
- Soft-tissue spectral subtraction improves transcutaneous Raman estimates of murine bone strength in vivo.Journal of biophotonics · 2020Article
- Treatments of osteoporosis increase bone material strength index in patients with low bone mass.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Normative Data for Impact Microindentation for Australian Men: Cross-Sectional Data From the Geelong Osteoporosis Study.JBMR plus · 2020Article
- PTH and bone material strength in hypoparathyroidism as measured by impact microindentation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- In Vivo Assessment of Cortical Bone Fragility.Current osteoporosis reports · 2020Review
- Clinical measurements of bone tissue mechanical behavior using reference point indentation.Clinical reviews in bone and mineral metabolism · 2018Article
- Structural and functional properties of bone are compromised in amyotrophic lateral sclerosis mice.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2018Article
- Mechanical Characterization of Bone: State of the Art in Experimental Approaches-What Types of Experiments Do People Do and How Does One Interpret the Results?Current osteoporosis reports · 2018Review
- Assessment of bone quality in patients with diabetes mellitus.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Review
- Determination of Elastic Modulus in Mouse Bones Using a Nondestructive Micro-Indentation Technique Using Reference Point Indentation.Journal of biomechanical engineering · 2018Article
- The Role of Matrix Composition in the Mechanical Behavior of Bone.Current osteoporosis reports · 2018Review
- Recent Advances in Understanding Bisphosphonate Effects on Bone Mechanical Properties.Current osteoporosis reports · 2018Review
- The challenges of diagnosing osteoporosis and the limitations of currently available tools.Clinical diabetes and endocrinology · 2018Review
- Microindentation - a tool for measuring cortical bone stiffness? A systematic review.Bone & joint research · 2017Article
- Bone material strength index as measured by impact microindentation is low in patients with fractures irrespective of fracture site.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Differences in sensitivity to microstructure between cyclic- and impact-based microindentation of human cortical bone.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
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4 authors.
Funding
Abstract
Although the gold standard for determining bones' mechanical integrity is the direct measure of mechanical properties, clinical evaluation has long relied on surrogates of mechanical properties for assessment of fracture risk. Nearly a decade ago, reference point indentation (RPI) emerged as an innovative way to potentially assess mechanical properties of bone in vivo. Beginning with the BioDent device, and then followed by the newer generation OsteoProbe, this RPI technology has been utilized in several publications. In this review we present an overview of the technology and some important details about the two devices. We also highlight select key studies, focused specifically on the in vivo application of these devices, as a way of synthesizing where the technology stands in 2015. The BioDent machine has been shown, in two clinical reports, to be able to differentiate fracture versus nonfracture patient populations and in preclinical studies to detect treatment effects that are consistent with those quantified using traditional mechanical tests. The OsteoProbe appears able to separate clinical cohorts yet there exists a lack of clarity regarding details of testing, which suggests more rigorous work needs to be undertaken with this machine. Taken together, RPI technology has shown promising results, yet much more work is needed to determine if its theoretical potential to assess mechanical properties in vivo can be realized.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.