ArticleBehavioural brain research2015
Combined effects of exposure to dim light at night and fine particulate matter on C3H/HeNHsd mice.
Article in Behavioural brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Association between exposure to air pollution during intrauterine life and cephalic circumference of the newborn.Environmental science and pollution research international · 2021Pooled it
- Article
- Dim light at night impacts circadian rhythms and Alzheimer's disease-like neuroinflammation and neuropathology in humanized APP SAA knock-in mice.bioRxiv : the preprint server for biology · 2025Article
- A comprehensive review/expert statement on environmental risk factors of cardiovascular disease.Cardiovascular research · 2025Review
- Effects of air and light pollution on brain and behavioral function: Potential synergy.Neuroscience and biobehavioral reviews · 2025Review
- Synergistic impact of air pollution and artificial light at night on memory disorders: a nationwide cohort analysis.BMC public health · 2025Article
- Short-term attributable risk and economic burden of hospital admissions for anxiety disorders due to air pollution: a multicity time-stratified case-crossover study.Environmental health : a global access science source · 2025Article
- Traffic-related air pollution significantly aggravates the detrimental effect of infections on the risk of Alzheimer's disease and other dementias, especially in non-carriers ofFrontiers in dementia · 2025Article
- Atmospheric carbon monoxide and hospitalization for mental and behavioral disorders: insights from a longitudinal study in Shijiazhuang.Frontiers in psychology · 2025Article
- Effects of dim light at night in C57BL/6 J mice on recovery after spinal cord injury.Experimental neurology · 2024Article
- Crosstalk between Oxidative Stress and Inflammation Caused by Noise and Air Pollution-Implications for Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Traffic-related air pollution andFrontiers in dementia · 2024Article
- Acute exposure to artificial light at night alters hippocampal vascular structure in mice.iScience · 2023Article
- Curcumin Ameliorates Neurobehavioral Deficits in Ambient Dusty Particulate Matter-Exposure Rats: The Role of Oxidative Stress.Neurochemical research · 2023Article
- Light at night disrupts biological clocks, calendars, and immune function.Seminars in immunopathology · 2022Review
- Different components of air pollutants and neurological disorders.Frontiers in public health · 2022Review
- Chronic circadian phase advance in male mice induces depressive-like responses and suppresses neuroimmune activation.Brain, behavior, & immunity - health · 2021Article
- Light at night during development in mice has modest effects on adulthood behavior and neuroimmune activation.Behavioural brain research · 2021Article
- Particulate Matter Exposure Exacerbates Amyloid-β Plaque Deposition and Gliosis in APP/PS1 Mice.Journal of Alzheimer's disease : JAD · 2021Article
- Dim Light at Night Exposure Induces Cold Hyperalgesia and Mechanical Allodynia in Male Mice.Neuroscience · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Air and light pollution contribute to fetal abnormalities, increase prevalence of cancer, metabolic and cardiorespiratory diseases, and central nervous system (CNS) disorders. A component of air pollution, particulate matter, and the phenomenon of dim light at night (dLAN) both result in neuroinflammation, which has been implicated in several CNS disorders. The combinatorial role of these pollutants on health outcomes has not been assessed. Male C3H/HeNHsd mice, with intact melatonin production, were used to model humans exposed to circadian disruption by dLAN and contaminated environmental air. We hypothesized exposure to 2.5 μm of particulate matter (PM2.5) and dLAN (5lx) combines to upregulate neuroinflammatory cytokine expression and alter hippocampal morphology compared to mice exposed to filtered air (FA) and housed under dark nights (LD). We also hypothesized that exposure to PM2.5 and dLAN provokes anxiety-like and depressive-like responses. For four weeks, four groups of mice were simultaneously exposed to ambient concentrated PM2.5 or FA and/or dLAN or LD. Following exposure, mice underwent several behavioral assays and hippocampi were collected for qPCR and morphological analyses. Our results are generally comparable to previous PM2.5 and dLAN reports conducted on mice and implicate PM2.5 and dLAN as potential factors contributing to depression and anxiety. Short-term exposure to PM2.5 and dLAN upregulated neuroinflammatory cytokines and altered CA1 hippocampal structural changes, as well as provoked depressive-like responses (anhedonia). However, combined, PM2.5 and dLAN exposure did not have additive effects, as hypothesized, suggesting a ceiling effect of neuroinflammation may exist in response to multiple pollutants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.