ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2016
Upper Airway Stimulation for Obstructive Sleep Apnea: Self-Reported Outcomes at 24 Months.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Trial
- Long-term follow-up of the German post-market study for upper airway stimulation for obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2020Trial
- Effects of upper-airway stimulation on sleep architecture in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2017Trial
- Selective upper airway stimulation for obstructive sleep apnea: a single center clinical experience.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Trial
- Interrelationship between Daytime Functional Outcomes and Psychological Distress in Patients with Obstructive Sleep Apnea: A Cross-Sectional Study.Pulmonary therapy · 2026Article
- Differential association of body mass index with hypoglossal nerve stimulation efficacy by pharyngeal collapse pattern in obstructive sleep apnea.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Hypoglossal Nerve Stimulation Therapy in a Belgian Cohort of Obstructive Sleep Apnea Patients.Life (Basel, Switzerland) · 2024Article
- Use of Hypoglossal Nerve Stimulation for Treating OSA in Military Patient Populations.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2024Review
- Clinical Characteristics of Older Adults Seeking Hypoglossal Nerve Stimulation for the Treatment of Obstructive Sleep Apnea.Ear, nose, & throat journal · 2024Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Comparison of readmission and complication rates between traditional sleep surgery and hypoglossal nerve stimulation.Laryngoscope investigative otolaryngology · 2022Article
- Effect of Upper Airway Stimulation in Patients with Obstructive Sleep Apnea (EFFECT): A Randomized Controlled Crossover Trial.Journal of clinical medicine · 2021Article
- Endotypic Mechanisms of Successful Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea.American journal of respiratory and critical care medicine · 2021Article
- Reduced genioglossus muscle activity caused by fluid overload in anesthetized rats.Physiological reports · 2020Article
- The Nonsurgical Sleep Medicine Physician Role in the Development of an Upper Airway Stimulation Program.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2020Article
- Nerve Stimulation for the Treatment of Obstructive Sleep Apnea.Sleep and biological rhythms · 2020Article
- Within-country migration and obesity dynamics: analysis of 94,783 women from the Peruvian demographic and health surveys.BMC public health · 2019Article
- The outcomes of hypoglossal nerve stimulation in the management of OSA: A systematic review and meta-analysis.World journal of otorhinolaryngology - head and neck surgery · 2019Review
- Patient experience with upper airway stimulation in the treatment of obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2019Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the long-term (24-mo) effect of cranial nerve upper airway stimulation (UAS) therapy on patient-centered obstructive sleep apnea (OSA) outcome measures.
methodsProspective, multicenter, cohort study of 126 patients with moderate to severe OSA who had difficulty adhering to positive pressure therapy and received the surgically implanted UAS system. Outcomes were measured at baseline and postoperatively at 12 mo and 24 mo, and included self- and bedpartner-report of snoring intensity, Epworth Sleepiness Scale (ESS), and Functional Outcomes of Sleep Questionnaire (FOSQ). Additional analysis included FOSQ subscales, FOSQ-10, and treatment effect size.
resultsSignificant improvement in mean FOSQ score was observed from baseline (14.3) to 12 mo (17.3), and the effect was maintained at 24 mo (17.2). Similar improvements and maintenance of effect were seen with all FOSQ subscales and FOSQ-10. Subjective daytime sleepiness, as measured by mean ESS, improved significantly from baseline (11.6) to 12 mo (7.0) and 24 mo (7.1). Self-reported snoring severity showed increased percentage of "no" or "soft" snoring from 22% at baseline to 88% at 12 mo and 91% at 24 mo. UAS demonstrated large effect size (> 0.8) at 12 and 24 mo for overall ESS and FOSQ measures, and the effect size compared favorably to previously published effect size with other sleep apnea treatments.
conclusionsIn a selected group of patients with moderate to severe OSA and body mass index ≤ 32 kg/m2, hypoglossal cranial nerve stimulation therapy can provide significant improvement in important sleep related quality-of-life outcome measures and the effect is maintained across a 2-y follow-up period.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.