ArticleMolecular microbiology2015
ArsP: a methylarsenite efflux permease.
Article in Molecular microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 109 citations in OpenAlex.
- Genome-based identification of heavy metal resistance-associated genes in Bacillus enclensis ABF750 isolated from the polluted sediment of Versova Creek.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Synergistic function of ars genes in arsenic detoxification and biosynthesis of organoarsenicals.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Arsenic efflux mechanisms in ectomycorrhizal mushrooms Hebeloma bulbiferum and Hebeloma sinapizans.Applied microbiology and biotechnology · 2026Article
- Arsenic migration and transformation, greenhouse gas dynamics, and their coupled relationships in paddy fields.Frontiers in microbiology · 2026Review
- Mechanisms of Arsenic Interaction inInternational journal of molecular sciences · 2025Review
- Genome Deletions and Rewiring of the Transcriptome Underlying High Antimonite Resistance inInternational journal of molecular sciences · 2024Article
- Growth substrate limitation enhances anaerobic arsenic methylation byApplied and environmental microbiology · 2024Article
- Adaptation to metal(loid)s in strain Mucilaginibacter rubeus P2 involves novel arsenic resistance genes and mechanisms.Journal of hazardous materials · 2024Article
- Purifying selection drives distinctive arsenic metabolism pathways in prokaryotic and eukaryotic microbes.ISME communications · 2024Article
- Discovery of a novel bacterial class with the capacity to drive sulfur cycling and microbiome structure in a paleo-ocean analog.ISME communications · 2023Article
- Arsenite Methyltransferase Diversity and Optimization of Methylation Efficiency.Environmental science & technology · 2023Article
- Transcriptional Control ofApplied and environmental microbiology · 2023Article
- Arsenic in medicine: past, present and future.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Review
- The ArsQ permease and transport of the antibiotic arsinothricin.Molecular microbiology · 2023Article
- Unexpected genetic and microbial diversity for arsenic cycling in deep sea cold seep sediments.NPJ biofilms and microbiomes · 2023Review
- AsgeneDB: a curated orthology arsenic metabolism gene database and computational tool for metagenome annotation.NAR genomics and bioinformatics · 2022Article
- ArsZ from Ensifer adhaerens ST2 is a novel methylarsenite oxidase.Environmental microbiology · 2022Article
- Meta-omics-aided isolation of an elusive anaerobic arsenic-methylating soil bacterium.The ISME journal · 2022Article
- Characterization of Two Highly Arsenic-Resistant Caulobacteraceae Strains ofInternational journal of molecular sciences · 2022Article
- Glutathione Is Involved in the Reduction of Methylarsenate to Generate Antibiotic Methylarsenite in Enterobacter sp. Strain CZ-1.Applied and environmental microbiology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Trivalent organoarsenic compounds are far more toxic than either pentavalent organoarsenicals or inorganic arsenite. Many microbes methylate inorganic arsenite (As(III)) to more toxic and carcinogenic methylarsenite (MAs(III)). Additionally, monosodium methylarsenate (MSMA or MAs(V)) has been used widely as an herbicide and is reduced by microbial communities to MAs(III). Roxarsone (3-nitro-4-hydroxybenzenearsonic acid) is a pentavalent aromatic arsenical that is used as antimicrobial growth promoter for poultry and swine, and its active form is the trivalent species Rox(III). A bacterial permease, ArsP, from Campylobacter jejuni, was recently shown to confer resistance to roxarsone. In this study, C. jejuni arsP was expressed in Escherichia coli and shown to confer resistance to MAs(III) and Rox(III) but not to inorganic As(III) or pentavalent organoarsenicals. Cells of E. coli expressing arsP did not accumulate trivalent organoarsenicals. Everted membrane vesicles from those cells accumulated MAs(III) > Rox(III) with energy supplied by NADH oxidation, reflecting efflux from cells. The vesicles did not transport As(III), MAs(V) or pentavalent roxarsone. Mutation or modification of the two conserved cysteine residues resulted in loss of transport activity, suggesting that they play a role in ArsP function. Thus, ArsP is the first identified efflux system specific for trivalent organoarsenicals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.