ArticleAddiction (Abingdon, England)2015
Under pressure: adolescent substance users show exaggerated neural processing of aversive interoceptive stimuli.
Article in Addiction (Abingdon, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Multilevel Correlates of Youth Delinquent Behaviors: An Exploratory Analysis of Socioeconomic Context, Psychological Traits, and Task-Based Neural Activation in the ABCD Study.Social science insights and applications · 2025Article
- Directed exploration is reduced by an aversive interoceptive state induction in healthy individuals but not in those with affective disorders.Molecular psychiatry · 2025Article
- Individuals with methamphetamine use disorder show reduced directed exploration and learning rates independent of an aversive interoceptive state induction.Communications psychology · 2025Article
- Directed exploration is reduced by an aversive interoceptive state induction in healthy individuals but not in those with affective disorders.medRxiv : the preprint server for health sciences · 2025Article
- Computational Mechanisms of Information-Seeking in Anxiety.Current topics in behavioral neurosciences · 2025Review
- Interoceptive Processing in Substance Use Disorders (SUDs): From the Neuroanatomy to Insights from Computational Models and Predictive Coding Frameworks.Current topics in behavioral neurosciences · 2025Review
- Interoception in Adolescence: Impacts on Mental Health and Adaptive Functioning.Current topics in behavioral neurosciences · 2025Review
- Interoception Within the Context of Impulsivity and Addiction.Current addiction reports · 2023Review
- A Meta-Analysis of fMRI Studies of Youth Cannabis Use: Alterations in Executive Control, Social Cognition/Emotion Processing, and Reward Processing in Cannabis Using Youth.Brain sciences · 2022Article
- Affect-Related Brain Activity and Adolescent Substance Use: A Systematic Review.Current behavioral neuroscience reports · 2022Article
- Alcohol use and interoception - A narrative review.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Psychosocial Factors Predict the Level of Substance Craving of People with Drug Addiction: A Machine Learning Approach.International journal of environmental research and public health · 2021Article
- Atypical interoception as a common risk factor for psychopathology: A review.Neuroscience and biobehavioral reviews · 2021Review
- Trait and State: Interoceptive Accuracy during Anticipation of Public Speaking in Junior Secondary Shy Students from an Eastern Province of China.International journal of environmental research and public health · 2021Article
- Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders.Scientific reports · 2021Observational
- Do Adolescents Use Substances to Relieve Uncomfortable Sensations? A Preliminary Examination of Negative Reinforcement among Adolescent Cannabis and Alcohol Users.Brain sciences · 2020Article
- Signatures of alcohol use in the structure and neurochemistry of insular cortex: a correlational study.Psychopharmacology · 2019Article
- Alterations in White Matter Microstructure and Connectivity in Young Adults with Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2019Article
- Altered anticipation and processing of aversive interoceptive experience among women remitted from bulimia nervosa.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Impact of intranasal oxytocin on interoceptive accuracy in alcohol users: an attentional mechanism?Social cognitive and affective neuroscience · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
aimsAdolescents with substance use disorders (SUD) exhibit hyposensitivity to pleasant internally generated (interoceptive) stimuli and hypersensitivity to external rewarding stimuli. It is unclear whether similar patterns exist for aversive interoceptive stimuli. We compared activation in the insular cortex and other brain regions during the anticipation and experience of aversive stimuli between adolescents with SUD and those without.
designCross-sectional experimental study with two groups.
participantsAdolescents (ages 15-17 years) with an alcohol or marijuana SUD (n=18) and healthy comparison subjects (CON, n=15). Participants were recruited by distributing flyers at local high schools.
settingKeck Imaging Center, University of California San Diego, CA, USA. MEASUREMENTS: Behavioral and neural responses to a continuous performance task with inspiratory breathing load recorded during an fMRI session. Questionnaires assessed life-time drug use, anxiety, sensation-seeking, impulsivity, affect and bodily awareness. Visual analog scales assessed drug craving and breathing load responses.
findingsAcross subjects, experience of breathing load elicited greater bilateral anterior and posterior insula (AI and PI, respectively) activation than anticipation (F(1,31)=4.16, P<0.05). SUD exhibited greater left AI and bilateral PI activation during breathing load than anticipation, compared with CON (F(1,31)=4.16, P<0.05). In contrast, CON showed greater activation during anticipation than breathing load in left PI, compared with SUD (F(1,31)=4.16, P<0.05).
conclusionsAdolescents with alcohol and marijuana substance use disorders may be hypersensitive to aversive interoceptive stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.