Evidence map›Paper›PMID 26234701›Full record

ReviewCNS spectrums2015

Neuroimaging endophenotypes in autism spectrum disorder.

Rajneesh Mahajan, Stewart H Mostofsky

Abstract readReview
In one paragraph

Review in CNS spectrums, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Molecular Dysregulation in Autism Spectrum Disorder.Journal of personalized medicine · 2021
    Review
  12. Article
  13. Article
  14. Quantitative Gait Analysis in Duplication 15q Syndrome and Nonsyndromic ASD.Autism research : official journal of the International Society for Autism Research · 2020
    Article
  15. Severe white matter damage in SHANK3 deficiency: a human and translational study.Annals of clinical and translational neurology · 2020
    Article
  16. Review
  17. The Use of Artificial Intelligence in Screening and Diagnosis of Autism Spectrum Disorder: A Literature Review.Soa--ch'ongsonyon chongsin uihak = Journal of child & adolescent psychiatry · 2019
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rajneesh Mahajan1Center for Neurodevelopmental and Imaging Research (CNIR),Kennedy Krieger Institute,Baltimore,Maryland,USA.
Stewart H Mostofsky1Center for Neurodevelopmental and Imaging Research (CNIR),Kennedy Krieger Institute,Baltimore,Maryland,USA.

Funding

ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BELCHER, HAROLYN MILLICENT EDITH · 1985 to 2007
$37.3M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI, SCHLAGGAR, BRADLEY L · 2014 to 2019
$7.9M
Motor Skill Learning in AutismR01NS048527 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2005 to 2012
$2.9M
Autism Speaks AS1739Autism Speaks AS2384Autism Speaks AS2506NCRR NIH HHS M01 RR000052NICHD NIH HHS U54 HD079123NINDS NIH HHS R01 NS048527NINDS NIH HHS R01NS048527-08
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that has a strong genetic basis, and is heterogeneous in its etiopathogenesis and clinical presentation. Neuroimaging studies, in concert with neuropathological and clinical research, have been instrumental in delineating trajectories of development in children with ASD. Structural neuroimaging has revealed ASD to be a disorder with general and regional brain enlargement, especially in the frontotemporal cortices, while functional neuroimaging studies have highlighted diminished connectivity, especially between frontal-posterior regions. The diverse and specific neuroimaging findings may represent potential neuroendophenotypes, and may offer opportunities to further understand the etiopathogenesis of ASD, predict treatment response, and lead to the development of new therapies.

Indexed as

Brain MappingEndophenotypesBrainChild Development Disorders, PervasiveHumansAutism spectrum disorderDTIendophenotypesMRIneuroimaging

Identifiers

PMID26234701
PMCPMC4523891

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.