ArticleCell2015
Circadian Rhythms in Rho1 Activity Regulate Neuronal Plasticity and Network Hierarchy.
Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 108 citations in OpenAlex.
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- Daily ultrastructural remodeling of clock neurons.Current biology : CB · 2025Article
- A rapid and dynamic role for FMRP in the plasticity of adult neurons.Nature communications · 2025Article
- Circadian Regulation of Neuronal Membrane Capacitance-Mechanisms and Implications for Neural Computation and Behavior.International journal of molecular sciences · 2025Review
- Photoperiodic plasticity of pigment-dispersing factor immunoreactive fibers projecting toward prothoracicotropic hormone neurons in flesh fly Sarcophaga similis larvae.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Glial Regulation of Circuit Wiring, Firing, and Expiring in theCold Spring Harbor perspectives in biology · 2024Review
- The Drosophila circadian clock gene cycle controls the development of clock neurons.PLoS genetics · 2024Article
- Suprachiasmatic nucleus VIPergic fibers show a circadian rhythm of expansion and retraction.Current biology : CB · 2024Article
- Tango-seq: overlaying transcriptomics on connectomics to identify neurons downstream ofbioRxiv : the preprint server for biology · 2024Article
- Cholinergic neurons trigger epithelial CaNature · 2023Article
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males.BMC genomics · 2023Article
- Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit.Neuron · 2022Article
- Circuit formation in the adult brain.The European journal of neuroscience · 2022Review
- CaveCrawler: an interactive analysis suite for cavefish bioinformatics.G3 (Bethesda, Md.) · 2022Article
- Genetic regulation of central synapse formation and organization in Drosophila melanogaster.Genetics · 2022Review
- Connectomic analysis of theeLife · 2022Article
- Circadian rhythms as modulators of brain health during development and throughout aging.Frontiers in neural circuits · 2022Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuronal plasticity helps animals learn from their environment. However, it is challenging to link specific changes in defined neurons to altered behavior. Here, we focus on circadian rhythms in the structure of the principal s-LNv clock neurons in Drosophila. By quantifying neuronal architecture, we observed that s-LNv structural plasticity changes the amount of axonal material in addition to cycles of fasciculation and defasciculation. We found that this is controlled by rhythmic Rho1 activity that retracts s-LNv axonal termini by increasing myosin phosphorylation and simultaneously changes the balance of pre-synaptic and dendritic markers. This plasticity is required to change clock network hierarchy and allow seasonal adaptation. Rhythms in Rho1 activity are controlled by clock-regulated transcription of Puratrophin-1-like (Pura), a Rho1 GEF. Since spinocerebellar ataxia is associated with mutations in human Puratrophin-1, our data support the idea that defective actin-related plasticity underlies this ataxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.