ArticleDevelopmental cognitive neuroscience2015
Impact of cannabis use on prefrontal and parietal cortex gyrification and surface area in adolescents and emerging adults.
Article in Developmental cognitive neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Cumulative exposure to cannabis and hippocampus MRI in middle age: results from the coronary artery risk development in young adults (CARDIA) study.Translational psychiatry · 2026Article
- Unraveling the Enigma of Cannabinoid Hyperemesis Syndrome: A Narrative Review of Diagnosis and Management.Cureus · 2025Review
- Cannabis use in adolescence and young adulthood and its effects on brain structure and function: a scoping review.Frontiers in psychiatry · 2025Review
- Review
- Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study.BMJ mental health · 2024Observational
- Transcriptional Alterations Induced by Delta-9 Tetrahydrocannabinol in the Brain and Gonads of Adult Medaka.Journal of xenobiotics · 2023Article
- Prospective, longitudinal study to isolate the impacts of marijuana use on neurocognitive functioning in adolescents.Frontiers in psychiatry · 2023Article
- Why should we ask binge drinkers if they smoke cannabis? Additive effect of alcohol and cannabis use on college students' neuropsychological performance.Addictive behaviors reports · 2021Article
- THC Exposure is Reflected in the Microstructure of the Cerebral Cortex and Amygdala of Young Adults.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Psychotic symptoms are associated with lower cortical folding in youth at risk for mental illnessJournal of psychiatry & neuroscience : JPN · 2020Article
- Assessing the Role of Cannabis Use on Cortical Surface Structure in Adolescents and Young Adults: Exploring Gender and Aerobic Fitness as Potential Moderators.Brain sciences · 2020Article
- Review
- A survey-wide association study to identify youth-specific correlates of major depressive episodes.PloS one · 2020Article
- Intrinsic Frontolimbic Connectivity and Mood Symptoms in Young Adult Cannabis Users.Frontiers in public health · 2019Article
- Longitudinal Alterations in Prefrontal Resting Brain Connectivity in Non-Treatment-Seeking Young Adults With Cannabis Use Disorder.Frontiers in psychiatry · 2019Article
- Adolescent Brain Surface Area Pre- and Post-Cannabis and Alcohol Initiation.Journal of studies on alcohol and drugs · 2018Article
- Cannabidiol for Treatment of Childhood Epilepsy-A Cross-Sectional Survey.Frontiers in neurology · 2018Article
- Abnormal cortical gyrification in criminal psychopathy.NeuroImage. Clinical · 2018Article
- Alterations in regional shape on ipsilateral and contralateral cortex contrast in children with unilateral cerebral palsy and are predictive of multiple outcomes.Human brain mapping · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundRegions undergoing maturation with CB1 receptors may be at increased risk for cannabis-induced alterations. Here, we examine the relationships between cannabis use and prefrontal (PFC) and inferior parietal gyrification and surface area (SA) in youth.
methodsParticipants included 33 cannabis users and 35 controls (ages 18-25). Exclusions included co-morbid psychiatric/neurologic disorders and heavy other drug use. Multiple regressions and Pearson r correlations examined the effects of cannabis use on gyrification, SA and cognition.
resultsCannabis use was associated with decreased gyrification in: ventral-medial PFC (RH: [FDR corrected p=.02], LH: [FDR corrected p=.02]); medial PFC (RH: [FDR corrected p=.02], LH: [FDR corrected p=.02]); and frontal poles (RH: [FDR corrected p=.02], LH: [FDR corrected p=.02]). No differences were observed in bilateral hemispheres, PFC, dorsolateral, ventrolateral, or inferior parietal ROIs. Cannabis use was associated with marginally decreased SA in left: medial PFC [FDR corrected p=.09], and ventral lateral PFC: [FDR corrected p=.09]. In cannabis users, increased gyrification was associated with improved working-memory performance in right medial (p=.003), ventral-medial (p=.03), and frontal pole ROIs (p=.007).
conclusionsCannabis use was associated with reduced gyrification in PFC regions implicated in self-referential thought and social cognition. Results suggest that these gyrification characteristics may have cognitive implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.